TY  - JOUR
TT  - Risk factors for brain metastases in patıents with advanced nonsmall Cell lung cancer
AU  - Keskin, Emine
AU  - Yaren, Arzu
AU  - Başer, Sevin
AU  - Tekekoğlu, Selma Dinçer
AU  - Değirmencioğlu, Serkan
PY  - 2009
DA  - April
JF  - Pamukkale Medical Journal
JO  - Pam Tıp Derg
PB  - Pamukkale Üniversitesi
WT  - DergiPark
SN  - 1308-0865
SP  - 24
EP  - 30
IS  - 1
KW  - Küçük hücreli dışı akciğer kanseri
KW  - beyin metastazı
KW  - risk faktörleri
N2  - We aimed to determine the risk factors for brain metastases among patients with advanced NSCLC. Aretrospective analysis was made for 163 advanced NSCLC patients. The patients were enrolled intotwo groups in terms of who developed brain metastases or not during follow-up. Age, gender,performance status, weight-loss, histopathologic type, localisation of the primary tumor, smokingstatus, response to treatment, and lactate dehydrogenase (LDH), albumin, heamoglobin levels at thetime of the diagnosis were analyzed by univariate and multivariate analysis. Cox proportional hazardmodel and Kaplan-Meier survival analysis.There were 40 (24.5%) patients who had brain metastasesat the follow-up. Risk factors for brain metastases were weight-loss, extracranial metastases, upperlocalisation of primary tumor, unresponsiveness of first-line chemotherapy regimen, mediastinal lymphnode involvement and high LDH level. Median survival was 44 weeks, overall survival rate at 1 yearwas 38%, median time to onset of brain metastases was 32 weeks and median survival from thediagnosis of brain metastases was 28 weeks. Weight-loss, extracranial metastases, upper localisationof primary tumor, unresponsiveness of first-line chemotherapy regimen, high LDH level andmediastinal lymph node involvement were the most important risk factors for the prediction of brainmetastases. Prophylactic cranial irradiation may be choise in those patients to delay brain relapse, toimprove quality of life and to decrease morbidity and mortality of brain metastases.
UR  - https://dergipark.org.tr/tr/pub/patd/issue//392568
L1  - https://dergipark.org.tr/tr/download/article-file/422280
ER  -