@article{article_392726, title={The comparison of oral versus subcutaneous administration of methotrexate in plaque type psoriasis: A 5 - year retrospective analysis}, journal={Pamukkale Medical Journal}, pages={131–135}, year={2011}, url={https://izlik.org/JA32MD49KL}, author={Taşlı, Levent and Kaçar, Nida and Yıldız, Necibe and Şanlı, Berna and Ergin, Şeniz}, keywords={Psoriazis, metotreksat, tedavi, subkutanöz, oral}, abstract={OBJECTIVE: Psoriasis is a common, chronic, infl ammatory, multisystem disease affecting approximately 2% of thepopulation. While oral methotrexate has been used in the treatment of psoriasis with success, subcutaneous(SC) form of methotrexate have also been developed. SC methotrexate has been recently found more effectivethan oral methotrexate in the same dosage in rheumatoid arthritis. In this study, we aimed to compare theeffi cacy and safety of SC versus oral administration of methotrexate in patients with psoriasis.METHODS: We analyzed the records of the patients with plaque psoriasis under methotrexatetherapy at our clinic from 2006 to 2010.RESULTS: Thirty patients (20 SC and 10 oral) were enrolled. The ratio of Psoriasis Area Severity Index (PASI) 50 achievement at 4 weeks was 50% in SC group whereas only 10% in oral group (p=0.04). While the total methotrexate dosage taken until PASI 50 achievement within 16 weeks was greater in oral group (p=0.039), total methotrexate dosage did not differ between the groups in terms of PASI 75 achievement (p>0.05). Mean PASI changes from baseline were comparable at 12 and 16 weeks between the groups (p>0.05).CONCLUSION: That the mean PASI changes from baseline were comparable at 12 and 16 weeks between the groups shows SC and oral methotrexate have no superiority to each other. PASI 50 was achieved with SC methotrexate in more patients for 4 weeks. SC methotrexate can be used as an induction therapy.}, number={3}