TY  - JOUR
T1  - Endosülfan ve C Vitamini Uygulamalarının Erkek Yeni Zellanda Tavşanları Üzerindeki Etkisi
TT  - Effects of Vitamin C on Male New Zealand White Rabbits Exposed to Endosulfan
AU  - Hatipoğlu, Fatma Şefika
AU  - Yıldız_gülay, Özlem
AU  - Büyükoğlu, Tülay
AU  - Gülay, Mehmet Şükrü
PY  - 2018
DA  - June
Y2  - 2018
DO  - 10.30607/kvj.394088
JF  - Kocatepe Veterinary Journal
JO  - kvj
PB  - Afyon Kocatepe Üniversitesi
WT  - DergiPark
SN  - 1308-1594
SP  - 165
EP  - 172
VL  - 11
IS  - 2
LA  - tr
AB  - Çalışmamızdaendosülfan uygulaması yapılan erkek Yeni Zellanda tavşanlarında C vitamini(VitC) ilavesinin bazı kan ve biyokimyasal parametreler ile oksidan-antioksidandenge üzerine düzeltici etkisinin araştırılması amaçlanmıştır. Bu amaçla,yaşları 6 ile 8 ay arasında değişen 24 tavşan, her grupta 6 tavşan olacakşekilde, rastgele 4 çalışma grubuna ayrıldı. Kontrol grubundaki tavşanlara(TRT-I) mısır yağı verildi. İkinci grupta bulunan tavşanlara (TRT-II) günlük 1mg/kg endosülfan mısır yağında eritilerek verildi. Üçüncü gruptakitavşanlara 20 mg/kg dozunda VitC günaşırı olarak uygulandı (TRT-III). Son gruptaki tavşanlara (TRT-IV) aynıoranlarda endosülfan ve VitC verildi. Oral yolla yapılan bu uygulamalar 6 haftaboyunca devam etti. Çalışmamızda toplam eritrosit ve trombosit, hemoglobin,hematokrit, ve lökosit değerleri yönünden gruplar arasında fark gözlenmezken,toplam lökosit sayılarında anlamlı bir fark bulundu. Ayrıca serum glukoz,alanin aminotransferaz (ALT), malondialdehit (MDA), glukoz 6 fosfatdehidrojenaz (G6PD), glutatyon peroksidaz (GPx) ve eritrosit katalaz (CAT) aktivitelerinde de farklılık tespit edilmedi.TRT-III grubunda serum VitC seviyesi yükselirken, TRT-II grubunda serum alkalenfosfataz (ALP) ve aspartat aminotransferaz (AST) seviyeleri arttı. Bununlabirlikte VitC uygulamasının TRT-IV grubundaki tavşanlarda ALP ve ASTseviyelerini TRT-II grubuna göre azalttığı gözlendi. Elde edilen bulgularagöre, VitC uygulamasının endosülfanın bazı zararlı etkilerine karşı erkek YeniZellanda tavşanlarında koruyucu olabileceği sonucuna varıldı.
KW  - kan parametreleri
KW  - biyokimyasal parametreler
KW  - oksidan-antioksidan denge
KW  - endosülfan toksikasyonu
KW  - insektisit kullanımı
KW  - Vitamin C
N2  - The present study evaluated the protectiveeffect of oral Vitamin C (VitC) against changes in hematological andbiochemical parameters, and oxidant-antioxidant status in male New ZealandWhite rabbits treated with endosulfan. Total of 24 rabbits (6 to 8 years old)were randomly divided into 4 treatment groups (n=6). Rabbits in the controlgroup (TRT-I) received corn oil for 6 weeks. Rabbits in the second group(TRT-II) received endosulfan (1 mg/kg bw per day) in corn oil. Rabbits in thethird group (TRT-III) received corn oil daily and VitC (20 mg/ kg bw) everyother day for 6 weeks. Rabbits in the last group (TRT-IV) received the sameamounts of endosulfan and VitC. All treatments were administered by oral route.Although total erythrocyte, trombocyte, hemoglobin and percent hematocrit,lymphocyte, granulocyte and monocyte did not differ among the treatment groups,total leukocyte numbers differed due to treatment. The serum glucose, alanineaminotransferase (ALT), malondialdehyde (MDA), glucose 6 phosphatedehydrogenase (G6PD), glutathion peroxidase (GPx), and erythrocyte catalase(CAT) in treatment groups were similar. However, serum VitC levels wereelevated for rabbits in TRT-II group. Inaddition, serum alkaline phosphatase (ALP) and aspartate aminotransferase (AST)levels increased in the TRT-II group, whereas VitC application decreased ALPand AST levels in the TRT-IV group when compared to the TRT-II group. Thus,results suggested beneficial influences of VitC in neutralizing some harmfuleffects of endosulfan in male New Zealand White rabbits.
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UR  - https://doi.org/10.30607/kvj.394088
L1  - https://dergipark.org.tr/tr/download/article-file/459544
ER  -