@article{article_394128, title={SURFACE MODIFICATION OF POLYMERIC NANOPARTICULATE DRUG}, journal={Journal of Faculty of Pharmacy of Ankara University}, volume={38}, pages={137–154}, year={2009}, DOI={10.1501/Eczfak_0000000522}, author={Sengel-turk C., Tuba and Hascicek, Canan}, keywords={Polimerik nanopartiküller, Nanopartiküler İlaç taşıyıcı sistemler, Yüzey modifikasyon teknikleri, yüzey modifikasyon ajanları}, abstract={Surface modification can be defined as the improvement and replacement of the surface properties of nano-sized drug delivery systems. In the field of pharmaceutical technology, surface modification provides several advantages to improve the physicochemical properties and pharmaceutical activities of many nanosized carriers particularly polymeric nanoparticles. The surface properties of the polymeric nanoparticulate drug delivery systems play a key role on the biological behaviour that is shown in the organism. By the modification of the surface properties of these systems, targeting potential and cellular uptake levels are increased, blood circulation times are prolonged, especially the accumulation in the tumor tissues is improved to higher levels. In this review, the defination and the advantages of the polymeric nanoparticulate systems, the benefits of surface modification, surface modification techniques and the studies in the pharmaceutical field concerning surface modification are covered}, number={2}, publisher={Ankara Üniversitesi}