@article{article_394133, title={SOLATION OF CHELIDONINE AS AN ANALGESIC COMPOUND FROM CHELIDONIUM MAJUS L}, journal={Journal of Faculty of Pharmacy of Ankara University}, volume={38}, pages={9–16}, year={2009}, DOI={10.1501/Eczfak_0000000513}, author={Saltan Çitoğlu, Gülçin and Özbek, Hanefi and Bahadır Acıkara, Özlem and Baıtz Gacs, Eszter}, keywords={Chelidonium majus, Papaveraceae, Kelidonin, Analjezik Aktivite, Tail-flik testi}, abstract={In this study the analgesic activity of chelidonine which was isolated from the aerial parts of Chelidonium majus (Papaveraceae), was investigated by using tail-flick test. Chelidonine is one of the main alkaloid in the aerial parts of C. majus. Isolation of chelidonine was performed by using chromatographic techniques. Spectroscopic (1H-NMR, 13C-NMR) and physical (melting point) methods were used for structure elucidation of the isolated compound. Analgesic activity of the compound was evaluated by using tail-flick test on mice at 5 mg/kg dose. Chelidonine produced higher analgesic activity than aspirine at 90th minute. However equivalent analgesic activity to aspirine was observed at 150th minute with chelidonine treatment}, number={1}, publisher={Ankara Üniversitesi}