@article{article_394169, title={EZRİN/ RADIXIN/ MOESIN (ERM) PROTEINS}, journal={Journal of Faculty of Pharmacy of Ankara University}, volume={37}, pages={295–309}, year={2008}, DOI={10.1501/Eczfak_0000000509}, author={Cihan, Ayla and Ark, Mustafa}, keywords={ERM Proteinleri}, abstract={The ERM family consists of three closely related proteins, ezrin, radixin and moesin. These proteins are responsible for the formation of links between plasma membrane proteins and the actin cytoskeleton. There are three regions of ERM proteins: N-terminal lipid and membrane binding domain called FERM, a central α-helical domain in the form coiled coils and F-actin binding C-terminal domain. ERM proteins are found in inactive state in the cytoplasm and can be activated with various signals such as treonine phosphorylation, Rhosignaling pathway. Also these proteins play an important role as positive and negative regulators of Rho family members in activation. ERM proteins are concentrated in actin-rich surface structures such as microvilli, filopodia and membrane ruffles. Active ERM proteins play a role in many events within cell such as microvillusshape, the regulation of organization of the channels . It has been shown that these proteins involve in many pathophysiological events especially in cancer}, number={4}, publisher={Ankara Üniversitesi}