TY  - JOUR
TT  - EFFECT OF GAMMA IRRADIATION STERILIZATION ON DRUG RELEASE  FROM IN SITU FORMING INJECTABLE IMPLANT SYSTEMS
AU  - Alğın Yapar, Evren
AU  - Baykara, Tamer
PY  - 2008
DA  - March
DO  - 10.1501/Eczfak_0000000487
JF  - Journal of Faculty of Pharmacy of Ankara University
JO  - J. Fac. Pharm. Ankara
PB  - Ankara Üniversitesi
WT  - DergiPark
SN  - 1015-3918
SP  - 1
EP  - 10
VL  - 37
IS  - 1
KW  - Gama radyasyonla sterilizasyon
KW  - Granisetron HCl
KW  - Poli(DL-laktid-ko-glikolid)
KW  - Enjekte edilebilen
KW  - In situ implant
N2  - The objective of this study was to evaluate effect of gamma irradiation sterilization on release of granisetron hydrochloride from injectable in situ implants prepared for suppressing emesis induced by radiotherapy for 21 days. Investigated formulations contain 32% (w/w) poly(DL-lactide-co-glycolide) 50:50 (PLGA) having varied molecular weight (Mw) (12, 18, 34 kDa), 64% (w/w) benzyl benzoate and 4% (w/w) drug. Formulations were injected by 20G needle independent of polymer type at this ratio, however injectability hardened by increasing Mw of polymer. Following injection of formulations into 10 ml phosphate buffered saline pH 7.4, in vitro dissolution test was carried out in a shaker bath (37oC, 30 rpm) for 21 daysand samples were analyzed by UV spectrophotometer. Drug release profiles were obtained for non-sterile and sterile form of three different formulations. Obtained profiles showed that initial drug burst decreased by increase in Mw of polymer and high Mw PLGA (-COOH end uncapped) provided more uniform release profile.Drug release accelerated and injectability facilitated for all formulations after sterilization by γirradiation. Sterilization showed a significant effect on in vitro drug release according to dissolution comparison test values of three coupled formulations which were all except the limits of f1=0-15 and f2=50100. Consequently injectable phase sensitive polymeric systems were found as sensitive to gamma irradiation sterilization
UR  - https://doi.org/10.1501/Eczfak_0000000487
L1  - https://dergipark.org.tr/tr/download/article-file/424400
ER  -