TY  - JOUR
TT  - LAST DEVELOPMENTS IN ANTIFUNGAL TREATMENT
AU  - Küçükoğlu, Kaan
PY  - 2008
DA  - March
DO  - 10.1501/Eczfak_0000000491
JF  - Journal of Faculty of Pharmacy of Ankara University
JO  - J. Fac. Pharm. Ankara
PB  - Ankara Üniversitesi
WT  - DergiPark
SN  - 1015-3918
SP  - 63
EP  - 90
VL  - 37
IS  - 1
KW  - Mantar enfeksiyonları
KW  - Antifungal ajanlar
KW  - Ekinokandinler
N2  - In the world, invasive fungal infections are increasing because of rising the numbers of immunocompromised patients. For over 50 years, amphotericin B deoxycholate has been the “gold standard” in the treatment of these infections, in spite of its toxic effects. However, during the last 15 years, new and improved therapy options for invasive fungal infections have been appeared. New triazoles and the echinocandins that were recently discovered have been added to antifungal therapy. The new triazole agents, voriconazole and posaconazole, have a broad spectrum of antifungal activity. Voriconazole has become the agent of choice for invasive aspergillosis. Posaconazole appears to be effective for the treatment of zygomycosis, too. Against invasive fungal infections echinocandins with unique mechanisms of action have similar spectrum of activity, pharmacokinetics and antifungal efficacy. These agents have been shown to be effective in the treatment of candidemia and invasive candidiasis
UR  - https://doi.org/10.1501/Eczfak_0000000491
L1  - https://dergipark.org.tr/tr/download/article-file/424407
ER  -