@article{article_394343, title={SUICIDE ATTEMPTS WITH TRICYCLIC ANTIDEPRESSANTS}, journal={Journal of Faculty of Pharmacy of Ankara University}, volume={33}, pages={255–267}, year={2004}, DOI={10.1501/Eczfak_0000000011}, author={Saygı, Şahan and Gül, Hüsamettin and Macit, Enis and Yamanel, Levent}, keywords={Trisiklik antidepresanlar, Kodein, Asetaminofen, GC/MS, FPIA}, abstract={Tricyclic antidepressant drugs (TCA) are the second widely used drugs after the analgesics, and involve in acute poisoning cases. In this study we measured unusual high dose of TCA levels in three suicidal poisoning cases. Toxicological screening on patients urine and blood samples were performed with GC/MS, and the quantitation of drugs were done with GC/MS and FPIA methods. Amitriptyline, acetaminophen, and codeine levels were 1135 ng/ml blood, 14.42 µg/ml blood, and 72.9 µg/ml urine respectively in case 1. Amitriptyline levels were found as 505, 429, and 370 ng/ml blood for consequent three days. In Case 2, amitriptyline levels were 883.56 and 137.35ng/ml blood for two days. In Case 3, initial imipramine level was 2560 ng/ml blood. First two patients were fully recovered 4 days after the incident. The third patient died 36 hours after the admission. In acute poisoning cases, early emergency teratment, obtaining rapid and reliable toxicological laboratory results were considered vitally important in poisoning cases}, number={4}, publisher={Ankara Üniversitesi}