@article{article_394487, title={A SELECTIVE SEARCH FOR BIOLOGICALLY ACTIVE BIPARTATE NUCLEOSIDE PRODRUGS: I}, journal={Journal of Faculty of Pharmacy of Ankara University}, volume={30}, pages={29–51}, year={2001}, DOI={10.1501/Eczfak_0000000359}, author={Ölgen, Süreyya}, keywords={Önilaç, Bipartat yaklaşım, Aktivite}, abstract={The primary goal of prodrug is to provide an effective and desired concentration of a parent drug at the target organ. This goal is usually achieved by improved absorption, but ideally this must occur without accompanying toxicity. For this aim, various alkyl and amino acid esters of nucleosides have been synthesized to inhibit metabolism and improve oral bioavailability. In this review, it was described important examples of prodrugs such as ddl, ara-A and AZT which are already in the market for treatment of HIV (Human Immunodeficiency Virus) and some other biologically active prodrugs that were synthesized recently}, number={2}, publisher={Ankara Üniversitesi}