TY  - JOUR
TT  - The Effects of Honeybee (Apis mellifera) Venom on the BloodPressure and the Infestinal Motility of the Guinea—pig
AU  - Altınkurt, Orhan
AU  - Altan, Melih
PY  - 1978
DA  - June
DO  - 10.1501/Eczfak_0000000421
JF  - Journal of Faculty of Pharmacy of Ankara University
JO  - J. Fac. Pharm. Ankara
PB  - Ankara Üniversitesi
WT  - DergiPark
SN  - 1015-3918
SP  - 40
EP  - 50
VL  - 8
IS  - 1
N2  - The venom extract obtained from the honeybees of the Ankara environment, giyen intravenously, produced a short—lived hypotension on the guinea—pig blood pressure. Usually the blood pressure was returned to its normal level in a short time. Sometimes this hypotensive effect was followed by a hypertension which lasted for 10 or 15 minutes. Similar effects had been reported by several investigators with scorpion venom on several laboratory animals. Although this initial hypotensive effect produced by the scorpion venom could be prevented with atropine, the same effect of the bee venom could not be blocked with it. However, Systral antagonized this hypotensive effect competitively. The bee venom extract constricted the guineapig ileum and this action of the extract was inhibited with Antistamin. But this antagonism is different from the effect on the blood pressure as being a noncompetitive one.
UR  - https://doi.org/10.1501/Eczfak_0000000421
L1  - https://dergipark.org.tr/tr/download/article-file/425424
ER  -