TY  - JOUR
T1  - EVALUATION OF THE OXIDATIVE STRESS IN SILICOSIS PATIENTS
AU  - Ünal, Kübranur
AU  - Çakır, Bağdagül
AU  - Demir Bal, Ceylan
AU  - Hınç Yılmaz, Ömer
AU  - Tutkun, Engin
AU  - Meriç Yılmaz, Fatma
PY  - 2018
DA  - February
JF  - The Turkish Journal Of Occupational / Environmental Medicine and Safety
JO  - turjoem
PB  - Engin TUTKUN
WT  - DergiPark
SN  - 2149-4711
SP  - 5
EP  - 5
VL  - 3
IS  - 1
LA  - en
AB  - ABSTRACTObjective. Silica particles are potent inducers of cellproliferation, cell injury, and inflammation, and oxidant release from alveolarmacrophages, thus providing a mechanistic framework for their increasedfibrogenicity. The Alveolar macrophages are viewed as a pivotal cell type infibrogenesis in both lung defense and elaboration of growth factors andoxidants. In this study, we aimed to investigate serum TAS(Total Antioxidant Status), TOS (Total Oxidant Status) and OSI (OxidativeStress Index) parameters in the individuals working in ceramic factory anddiagnosed as silicosis and discuss the possible effects of these parameters onthe etiopathogenesis of the disease. Methods.This study was performed on 33 male patients with silicosis (23-73 years)and 30 male healthy control (18-69 years) who were admitted to AnkaraOccupational Diseases Hospital. Silicosis patientswere diagnosed depending on their chest radiograms in accordance with the ILO2000 guidelines. TAS, TOS levels were measured in blood samples and OSIwas calculated according to formula (TOS/TAS).Results.Serum TOS levels of the silicosis subjects were higher than those of thecontrols whereas serum TAS levels of silicosis subjects was lower than those ofthe controls. But the differences between the parameters were not statisticallysignificant. The serum OSI levels were significantly higher (p<0.05) in thesilicosis subjects compared with the control group.Conclusion. Ourstudy showed elevated OSI in patients with silicosis. Increased oxidativestress is thougth to be related with the oxidative burst caused by alveolarmacrophage activation.Keywords.Silicosis, Total AntioxidantStatus, Total Oxidant Status, Oxidative StressConflictof interest: Authors do not have any conflict of interest
KW  - EVALUATION OF THE OXIDATIVE STRESS IN SILICOSIS PATIENTS
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UR  - https://dergipark.org.tr/tr/pub/turjoem/issue//396602
L1  - https://dergipark.org.tr/tr/download/article-file/427713
ER  -