TY - JOUR T1 - Primer Lokalize Kutanöz Amiloidoz ve Diffüz Sistemik Skleroz Birlikteliği: Olgu Sunumu TT - Co-existence of Primary Localized Cutaneous Amyloidosis and Diffuse Systemic Sclerosis: Case Report AU - Tarhan, Emine Figen AU - Koca, Emine PY - 2018 DA - December JF - Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi JO - MMJ PB - Muğla Sıtkı Koçman Üniversitesi WT - DergiPark SN - 2148-8118 SP - 37 EP - 38 VL - 5 IS - 3 LA - tr AB - Primer lokalize kutanöz amiloidoz ve diffüzsistemik skleroz birlikteliği nadirdir. 15 yıl önce biyopsi ile primer lokalizekutanöz amiloidoz tanısı alan 61 yaşındaki bir kadın hastaya deri ve lokomotorsistem bulguları, kapilleroskopi bulguları ve otoantikor (anti-Scl-70)pozitifliği ile diffüz sistemik skleroz tanısı konulmuştur. Farklı klinik,etiyopatogenetik ve genetik özellikleri olan bu iki hastalık nadiren bir aradagörülmektedir. KW - Amiloidozis KW - CREST KW - Sistemik Skleroz N2 - Co-existence ofprimary localized cutaneous amyloidosis and diffuse systemic sclerosis is veryrare. In a 61-year-old woman who was diagnosed as primary localized cutaneousamyloidosis with biopsy 15 years ago, additional diagnosis of diffuse systemicsclerosis was made based upon skin, locomotor system and capilloroscopy findingsand autoantibody (anti- Scl70) positivity. These two autoimmune diseases, whichhave different aetiopathogenesis as well as diverse clinical and geneticcharacteristics, are rarely seen together. CR - 1. Husby G. Nomenclature and classification of amyloid and amyloidosis. J Intern Med. 1992;232(6):511-2. CR - 2. Kyle RA, Greipp PR. Amyloidosis (AL). Clinical and laboratory features in 229 cases. Mayo Clin Proc. 1983; 58(10):665-83. CR - 3. Mehrotra K, Dewan R, Kumar JV, Dewan A. Primary Cutaneous Amyloidosis: A Clinical, Histopathological and Immunofluorescence Study. J Clin Diagn Res. 2017;11(8):WC01-WC05. CR - 4. Krishna A, Nath B, Dhir GG, Kumari R, Budhiraja V, Singh K. Study on epidemiology of cutaneous amyloidosis in northern India and effectiveness of dimethylsulphoxide in cutaneous amyloidosis. Indian Dermatol Online J. 2012;3(3):182-86. CR - 5. Al-Ratrout JT, Satti MB. Primary localized cutaneous amyloidosis: A clinicopathologic study from Saudi Arabia. Int J Dermatol. 1997;36(6):428-34. CR - 6. Denton CP, Khanna D. Systemic sclerosis. Lancet. 2017;7;390(10103):1685-99. CR - 7. Breathnach SM. Amyloid and Amyloidosis. J Am Acad. Dermatol. 1988;(18); 1-16. CR - 8. Kikuchi N, Sakai E, Nishibu A, Ohtsuka M, Yamamoto T. Primary Localized Cutaneous Amyloidosis in Patients with Scleroderma Acta Derm Venereol. 2010;90(3):326-7. CR - 9. Ogiyama Y, Hayashi Y, Kou C, Matsumoto Y, Ohashi M. Cutaneous amyloidosis in patients with progressive systemic sclerosis. Cutis. 1996; 57(1): 28–32. CR - 10. Summers EM, Kendrick CG. Primary localized cutaneous nodular amyloidosis and CREST syndrome: a case report and review of the literature. Cutis. 2008;82(1):55-9. CR - 11. Shiman M, Ricotti C, Miteva M, Kerdel F, Romanelli P. Primary localized cutaneous nodular amyloidosis associated with CREST (calcinosis, Raynaud’s phenomenon, esophageal motility disorders, sclerodactyly, and telangiectasia) syndrome. Int J Dermatol. 2010;49(2):229-30. UR - https://dergipark.org.tr/tr/pub/muskutd/issue//409416 L1 - https://dergipark.org.tr/tr/download/article-file/585375 ER -