TY - JOUR T1 - The Relation Between Blood Pressure Reverse-Dipping and Neutrophil to Lymphocyte Ratio in Hypertensive Patients TT - Hipertansif Hastalarda Reverse-dipper Kan Basıncı ile Nötrofil Lenfosit Oranı Arasındaki İlişki AU - Tek, Müjgan AU - Ayerden Ebinç, Fatma AU - Aybal Kutlugün, Aysun AU - Kaplan Efe, Fatma AU - Çetin, Serkan AU - Çelebi, Savaş AU - Berkalp, Berkten PY - 2019 DA - July DO - 10.20515/otd.410269 JF - Osmangazi Tıp Dergisi PB - Eskişehir Osmangazi Üniversitesi WT - DergiPark SN - 1305-4953 SP - 203 EP - 207 VL - 41 IS - 3 LA - en AB - Reverse dipper hypertensionand neutrophil to lymphocyte ratio (NLR)has been investigated as a predictor for cardiovascular risk. The relationshipbetween NLR and other circadien blood pressure (BP) patterns has been showed.The aim of this study was to investigate the relation between NLR and BPreverse dipper pattern in patients with hypertension. 144 hypertensive patients(66 males, 78 females) were enrolled the study. BP patterns were evaluated with24-h ambulatory BP monitoring (ABPM). Baseline NLR was measured by dividingneutrophil count to lymhocyte count. There was significantly increased NLR inreverse dippers (2,36±1,68 ) than dippers (1,81±0,69) of hypertension (p=0,040). NLR was negatively correlated with the decline rate of nocturnal systolic BP(r=-0,193;p=0.021)and diastolic BP( r=-0,160; p=0,057). Our study provides a possible associationbetween NLR and reverse dipper pattern, but to report NLR as an independentpredictor of reverse dipper pattern further studies are required. KW - NLR KW - reverse - dipper N2 - Revers dipper hipertansiyon ve nötrofil/lenfositoranı (NLR), kardiyovasküler risk öngördürücüsü olarak araştırılmaktadır. NLRve diğer sirkadyen kan basıncı paternleri arasındaki ilişki gösterilmiştir. Buçalışmanın amacı hipertansif hastalarda nötrofil lenfosit oranı ile reversdipper kan basıncı paterni arasındaki ilişkiyi değerlendirmektir. Çalışmaya 144 (66 erkek, 78 kadın)hipertansif hasta alındı. Kan basıncı paternleri 24 saat ambulatuar kan basıncıile değerlendirildi. Nötrofil lenfosit oranı, nötrofil sayısı lenfosit sayısınabölünerek ölçüldü. Revers dipper hipertansiyonlularda dipperhipertansiyonlulara göre nötrofil lenfosit oranında anlamlı artış vardı.(sırasıyla 2.36±1,68 ve 1,81±0,69, p=0,040 ). Nötrofil lenfosit oranı ilesistolik (r=-0,193;p=0.021 ve diyastolik ( r=-0,160; p=0,057) kan basıncı düşmeoranları arasında negatif korelasyon vardı.Çalışmamız NLR ve revers dipper patern arasında olası bir ilişkisunmaktadır ancak nötrofil lenfosit oranını,revers dipper paternin bağımsızöngörücüsü olarak rapor etmek için daha ileri çalışmalar gereklidir. CR - 1. Pickering TG, Shimbo D, Haas D. Ambulatory blood-pressure monitoring. N Engl J Med. 2006;354:2368-2374. DOI:10.1056/NEJMra060433. PubMed PMID: 16738273. CR - 2. McAlister FA, Straus SE. Evidence based treatment of hypertension. 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The relationship between red blood cell distribution width and blood pressure abnormal dispping in patients with essential hypertension: a cross-sectional study. BMJ Open 2016;6:e010456. doi: 10.1136/bmjopen-2015-010456. PMID:26908530. UR - https://doi.org/10.20515/otd.410269 L1 - http://dergipark.org.tr/tr/download/article-file/546912 ER -