TY  - JOUR
T1  - DETERMINATION OF CLOMIPRAMINE HYDROCHLORIDE FROM ITS COMMERCIAL DRUG FORM BY VOLTAMMETRY
TT  - DETERMINATION OF CLOMIPRAMINE HYDROCHLORIDE FROM ITS COMMERCIAL DRUG FORM BY VOLTAMMETRY
AU  - Yağmur, Sultan
AU  - Uğurlu, Elif
AU  - Yılmaz, Selehattin
PY  - 2018
DA  - January
JF  - Journal of Scientific Perspectives
JO  - JSP
PB  - Holistence Publications
WT  - DergiPark
SN  - 2587-3008
SP  - 1
EP  - 8
VL  - 2
IS  - 1
LA  - en
AB  - In this study, electroanalytical technique wasdeveloped for the quantitative analysis of clomipramine hydrochloride from itscommercial tablet dosage forms based on its oxidation behavior. Theelectrochemical determination of clomipramine hydrochloride was easily carried out on glassy carbonelectrode (GCE) by two voltammetric techniques. The electrochemical measurements were carried out on GCE surface indifferent buffer solutions in the pH range from 2.00 to 12.00 by cyclicvoltammetry (CV) and differential pulse voltammetry (DPV) techniques.  The effect of pH on the anodic peak currentand peak potential was investigated. Phosphate buffer (pH 6.50) was selectedfor analytical purposes.  Thediffusion-controlled nature of the peak was obtained.   A linear calibration plot for DPV analysiswas constructed in the clozapine concentration range from 5x10-6 molL-1 to 3x10-5 mol L-1. Limit of detection(LOD) and limit of quantification (LOQ) were obtained as 2.8x10-7mol L-1 and 8.4x10-7 mol L-1 respectively. 
KW  - clomipramine hydrochloride
KW  - oxidation
KW  - voltammetry
KW  - GCE
CR  - REFERENCES
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UR  - https://dergipark.org.tr/tr/pub/jsp/issue//410434
L1  - https://dergipark.org.tr/tr/download/article-file/448629
ER  -