TY - JOUR T1 - Çocukluk Çağında Dev Disgerminomlu Üç Olgu TT - Three Cases of Giant Childhood Dysgerminomas AU - Acıpayam, Can AU - Duyuran, Ömer AU - İnan, Merve Nur Yenmiş AU - Güler, Ahmet Gökhan AU - Karakaya, Ali Erdal AU - Bahar, Abdulkadir Yasir AU - Yurttutan, Nursel PY - 2018 DA - July Y2 - 2018 DO - 10.17517/ksutfd.411516 JF - Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi JO - KSU Medical Journal PB - Kahramanmaraş Sütçü İmam Üniversitesi WT - DergiPark SN - 1303-6610 SP - 59 EP - 62 VL - 13 IS - 2 LA - tr AB - Disgerminom, dev boyutlara ulaşabilen overin en sık görülen maligntümörüdür. Genelde hormon salgılamamakla beraber beta-HCG salgılayabilirler. Bizdekarında kitle ve karın ağrısı şikâyetleri olan radyolojik görüntüleme iletespit edilen beta-HCG salgılayan dev boyutlara ulaşmış disgerminom tanılı 3olguyu inceledik. Üç olguya da salpingo-ooferektomiameliyatı yapıldı. Bir olguda komsu lenf nodlarından, peritondan ve karşıoverden örnekleme yapıldı. Bir olgu da üç haftada bir dört kür BEP (Bleomisin, Etoposid, Sisplatin)kemoterapi protokolü ile fertilite de korunarak tedavi sağlanmış oldu. Birolguda da 3 kür BEP kemoterpi protokülü verilmesi planlandı ve 2 kür BEPkemoterapi protokolü verildi. KW - Disgerminom KW - Çocukluk Çağı N2 - Disgerminomais the most common malign tumor of the ovary that can reach giant sizes. Ingeneral, although they do not secrete hormones, they may secrete hormones, theymay secrete beta-HCG. We have studied 3 cases of disgerminoma that have reachedgiant dimensions that secrete beta-HCG detected by radiological imaging, whichcaused a complaint of abdominal pain in the abdomen. Salpingo-oophorectomywas performed in all three cases. In one case, neighboringlymph nodes, peritoneum and counter-ovary were sampled. In one case, once inthree weeks, four times treatment of BEP (Bleomycn, Etoposide, Cisplatin)chemotherapy protocol was administered and treatment was provided withoutharming fertility. In another case, three treatment BEP chemotherapy protocolwas planned to administer and two treatment BEP chemotherapy protocol wasperformed. CR - 1. Akyüz C, Varan A, Büyükpamukçu N, Kutluk T, Büyükpamukçu M. Malignant ovarian tumors in children: 22 years of experience at a single institution. J Pediatr Hematol Oncol 2000; 22:422-7.2. Fotiou SK. Ovarian malignancies in adolescence. Ann N Y Acad Sci 1997;816:338-3463. Zaloudek CJ, Tavassoli FA, Norris DJ. Dysgerminoma with syncytiotrophoblastic giant cells: a histologically and clinically distinctive subtype of dysgerminoma. Am J Surg Pathol 1981;5:361-7.4. Lanzkowsky P. Manual of pediatric hematology and oncology. Elsevier Inc California 4th ed. 2005:652-5.5. Williams SD, Gershenson DM, Horowitz CJ, Silva E. Ovarian germ cell tumors. In eds. Hoskins WJ, Perez CA, Young RC. Principles and practice of gynecologic oncology. III. th edition. 2000, Philadelphia, Lippincott. Williams and Wilkins Company, 1059-1074.6. Tsai JY, Saigo PE, Brown C, La Quaglia MP. Diagnosis, pathology, staging, treatment, and outcome of epithelial ovarian neoplasia in patients age < 21 years. Cancer 2001;91:2065-2070.7. Imai A, Furui T, Tamaya T. Gynecologic tumors and symptoms in childhood and adolescence; 10-years' experience. Int J Gynaecol Obstet 1994;45:227-2348. Deprest J, Moerman P, Corneillie P, Ide P. Ovarian borderline mucinous tumor in a premenarchal girl: review on ovarian epithelial cancer in young girls. Gynecol Oncol 1992;45:219-224. UR - https://doi.org/10.17517/ksutfd.411516 L1 - https://dergipark.org.tr/tr/download/article-file/479299 ER -