TY  - JOUR
T1  - Clinical Evaluation of Efficacy and Safety of Combined Topical Timolol and Oral Propranolol in Children with Infantile Hemangioma
AU  - Abdulhameed, Abdulameer Abdulbari
AU  - Al-hamdi, Kalil Esmail
AU  - Mathkoor, Muntaha Abdulhadi
PY  - 2018
DA  - March
DO  - 10.5799/jcei.413049
JF  - Journal of Clinical and Experimental Investigations
JO  - J Clin Exp Invest
PB  - Aydın ECE
WT  - DergiPark
SN  - 1309-8578
SP  - 1
EP  - 8
VL  - 9
IS  - 1
LA  - en
AB  - Objective:To evaluate theefficacy and safety of combined topical timolol and oral propranolol intreatment of infantile hemangioma. Patientsand methods: Thisprospective study was conducted in Basra teaching hospital in Basra, Iraq,where a total of 23 infants with 34 lesions of different types of hemangiomawere included. All lesions were in proliferation phase. The infants’ ages wereless than one year. They were treated with topical timolol solution 0.5%combined with oral propranolol in a period of 12 weeks (8-16 weeks). Theresponse to treatment was evaluated clinically by using hemangioma score andVisual analogue scale. All infants followed 4-12 months after cessation ofdrugs. Results:By usinghemangioma score system; the combined therapy showed that, 28 (82.4%) lesionsshowed excellent response, two (5.9%) showed good response, four (11.8%) showedfair response and none of the lesions showed poor response at end of 16 weeks.At the end of 4 months superficial hemangioma showed 100% reduction in theirscore, while the ulcerative hemangioma showed 94.7% reduction in their scorewhile mixed hemangioma showed only 76.7% reduction in their scores. Completeresolution occurred in 50% of lesions after 4 months of treatment. Neitherincluded infants developed serious side effects nor, any of the regressedhemangioma recur during the follow up. Conclusion:Combinedtopical Timolol 0.5% solution and oral propranolol seems to be awell-tolerated, safe treatment option with a good to excellent responses. Themost responsive type of hemangioma to this combination are the superficial andulcerative types. 
KW  - Hemangioma
KW  - children
KW  - treatment
KW  - timolol
KW  - propranolol
KW  - outcome
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UR  - https://doi.org/10.5799/jcei.413049
L1  - https://dergipark.org.tr/tr/download/article-file/453671
ER  -