@article{article_414145, title={C-Reactive Protein and Serum Amyloid A in Male Dogs after Orchiectomy}, journal={Erciyes Üniversitesi Veteriner Fakültesi Dergisi}, volume={15}, pages={37–40}, year={2018}, author={Hadžimusić, Nejra}, keywords={CRP,köpekler,orşiektomi,SAA}, abstract={<p>The acute-phase response is considered part of the innate immune system. During acute phase response, </p> <p>concentrations of acute phase proteins occur. Therefore, acute-phase proteins are part of the innate immune response </p> <p>and its biological function, although variable, generally relate to defense to pathological damage and restoration of </p> <p>homeostasis. Their levels fluctuate in response to inflammation and tissue injury. The main acute-phase proteins in </p> <p>dogs are C-reactive protein (CRP) and serum amyloid A (SAA). Surgical trauma has effect on many parts of immunological </p> <p>and hematological profile. The aim of this study was to determine the perioperative dynamics of CRP and SAA </p> <p>in male dogs undergoing elective orchiectomy. Blood samples were collectedby jugular venipuncture in the following </p> <p>order: before the surgery (day zero), on first (day one), third (day three) and seventh (day seven) postoperative day </p> <p>(POD). As markers of systemic inflammation, CRP and SAA levels was determined by ELISA using commercial kits. </p> <p>The study showed that the CRP and SAA changes rapidly. The peak CRP and SAA concentrations were detected on </p> <p>the first day after surgery. Serum CRP concentration on the seventh postoperative day was within physiological ranges, </p> <p>while SAA concentration was significantly higher. In conclusion, SAA and CRP measurements above basal levels </p> <p>are clearly indicative of systemic inflammation in dogs. </p>}, number={1}, publisher={Erciyes Üniversitesi}