TY  - JOUR
T1  - Delirium and tremor associated with ertapenem treatment
TT  - Ertapenem tedavisine bağlı gelişen deliryum ve tremor
AU  - Köse, Hatice
AU  - Temoçin, Fatih
PY  - 2018
DA  - March
DO  - 10.19161/etd.414446
JF  - Ege Tıp Dergisi
JO  - EJM
PB  - Ege Üniversitesi
WT  - DergiPark
SN  - 1016-9113
SP  - 60
EP  - 63
VL  - 57
IS  - 1
LA  - en
AB  - Though seizures are the most commonly reported neurotoxic adverse effects of ertapenem, there are numerousother side effects including hallucinations, disorientation, and tremors which are hardly ever reported. These sideeffects can be life-threatening, in the case of continued use of ertapenem. However, these treatment-related sideeffects completely resolve with discontinuation of the treatment. A 60-year-old female patient underwent hemodialysisowing to acute kidney insufficiency. Ertapenem was used to treat the condition since cultures from blood and urinesample of the patient showed growth of extended-spectrum beta-lactamase positive Escherichia coli. It was seen thatthe patient experienced tremors in the hand on the sixth day of the treatment, and hallucinations, disorientation,aggression, impaired speech as well as gait disturbances on the eighth day. With the discontinuation of ertapenemtreatment, all these symptoms disappeared within 72 hours. This paper emphasizes on the neurotoxicity other thanseizures resulting from ertapenem.
KW  - ertapenem
KW  - delirium
KW  - tremor
KW  - hallucination.
N2  - Ertapeneme bağlı nörotoksik yan etkilerden nöbet sıklıkla bildirilmesine rağmen, halüsinasyon, dezoryantasyon, tremor gibi nöbet dışı yan etkiler nadiren bildirilmiştir. Bu yan etkiler ertapenem kullanılmasının devam etmesi durumunda hayatı tehdit edici boyutlara ulaşabildiği gibi, kesilmesi durumunda tamamen gerilemektedir. Altmış yaşında kadın hasta akut böbrek yetmezliği nedeniyle hemodiyalize girmiş, kan ve idrar kültüründe genişletilmiş spekrumlu beta laktamaz pozitif Escherichia coli üremesi nedeniyle ertapenem başlanmıştır. Ertapenem tedavisinin altıncı gününde ellerinde tremor ve sekizinci gününde halusinasyon, dezoryantasyon, saldırganlık, konuşma ve yürüme bozukluğu başlamış, tedavi kesildikten sonra 72 saat içinde tüm bulgular gerilemiştir. Ertapeneme bağlı nöbet dışı nörotoksisiteye dikkat çekmek amacıyla bu olgu bildirilmiştir.
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UR  - https://doi.org/10.19161/etd.414446
L1  - https://dergipark.org.tr/tr/download/article-file/456338
ER  -