TY - JOUR T1 - Lipin Protein Ailesi AU - Vanizör Kural, Birgül AU - Kör, Sevil PY - 2018 DA - September JF - Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi JO - Gümüşhane Sağlık Bilimleri Dergisi PB - Gümüşhane Üniversitesi WT - DergiPark SN - 2146-9954 SP - 102 EP - 107 VL - 7 IS - 3 LA - tr AB - Lipinproteinleri hem fosfatidik asidin diaçilgliserole defosforilasyonunukalatizleyen fosfatitat fosfataz enzimi olarak hem de DNA-bağımlı transkripsiyon faktörlerininkoregülatörü olarak fonksiyon görürler. Bu fonksiyonları ile özellikletriaçilgliserol ve fosfolipid metabolizmasında önemli rol üstlenirler. Lipinprotein genleri insan için LPIN genive diğer memeliler için lpin genişeklinde ifade edilmektedir. Memelilerde doku spesifik ekspresyonlarına göre lipin-1, lipin-2 velipin-3 olmak üç lipin paralogu vardır. Ayrıca lipin-1’in insanda a, β ve g izoformları mevcuttur. 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