@article{article_430874, title={Genotoxic and Antigenotoxic Effects of Some Plant Species of Lamiaceae Family}, journal={Avrupa Bilim ve Teknoloji Dergisi}, pages={348–352}, year={2018}, DOI={10.31590/ejosat.430874}, author={Kilic, Dudu Duygu and Ayar, Arif and Baskan, Ceren and Yildirim, Tuba}, keywords={Lamiaceae,Drosophila melanogaster,plazmit DNA}, abstract={<p> <span style="font-size:12pt;line-height:115%;font-family:’Times New Roman’, serif;">Lamiaceae family is one of the members of important plants, using as a agents for alternative medicine treatments. Our aim was to investigate both antigenotoxic and genotoxic effects three different plants species belonging to Lamiaceae family: <i>Stachys annua, Scutellaria salviifolia, Nepeta nuda </i> in Amasya, using SMART ( <i>Drosophila melanogaster </i> somatic mutation and recombination test) and also plasmid DNA interaction method, respectively. SMART analyses revealed that genotoxic effect of ethyl methanesulfonate (EMS) was eliminated by plant extract of <i>S. salviifolia </i>, indicating antigenotoxic effects.  Different extract concentrations [(0.1, 0.25, 0.50 and 1 % (v/v)] of other plants species decrased the flecks number on <i>D. melanogaster </i> but the results did not show any statistical significance ( <i>p>0.05 </i>). In addition to SMART, interaction with pUC18 plasmid DNA was also analysed by using all concentrations (50 µg/mL-3.125 µg/mL) of plant extracts <i>N. nuda </i> and <i>S. annua. </i> The extracts did not cause changed in Form I DNA (supercoil) but trasferred from Form II DNA (open circular) to Form III DNA. Moreover, there was no effect of <i>S. salviifolia </i> plant extracts on DNA and band density. SMART results were supported by DNA interaction analyses, cocncluding that <i>S. salviifolia </i> plants indicated the high-impact antigenotoxic effect, but not genotoxic effects. </span> <br /> </p>}, number={14}, publisher={Osman SAĞDIÇ}