@article{article_432886, title={Clinical use of specific markers TAS, TOS, PON and IL-6 by the evaluation of kidney damage in patients receiving SWL treatment}, journal={Turkish Journal of Clinics and Laboratory}, volume={9}, pages={173–178}, year={2018}, DOI={10.18663/tjcl.432886}, author={Yuvanc, Ercan and Tuglu, Devrim and Gur, Serhan and Ozan, Tunc and Kısa, Üçler and Batislam, Ertan and Yılmaz, Erdal}, keywords={Şok Dalga Litotripsi (SWL), Toplam Antioksidan Status (TAS), Toplam Oksidan Status (TOS), Oksidatif Stres İndeksi (OSI), Paraoksonaz-1 (PON-1), İnterlökin-6 (IL-6)}, abstract={<p class="MsoNormal" style="text-align:justify;line-height:150%;"> <b> <span style="font-size:12px;line-height:150%;font-family:’Times New Roman’, serif;">Aim: </span> </b> <span lang="en-us" style="font-size:12px;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us">Beside efficacy of the shock wave
lithotripsy (SWL) procedure, also its negative effects on the kidneys, its relation
with the oxidant/antioxidant balance and the search after biomarkers for the
detection of this negative effect gained interest in the recent years. The aim
of the study is to investigate the possible usage of  total antioxidant status (TAS), total oxidant
status (TOS), oxidative stress index (OSI), Paraoxonase-1    (PON-1) and Interleukin 6 (IL-6) parameters
as biomarkers for renal injury/trauma  in
the early period by patients undergoing SWL due to kidney stones. </span> </p> <p> </p> <span style="font-size:12px;"> </span> <p class="MsoNormal" style="text-align:justify;line-height:150%;"> <b> <span style="font-size:12px;line-height:150%;font-family:’Times New Roman’, serif;">Material
and Methods: </span> </b> <span style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;"> <span style="font-size:12px;"> </span> <span lang="en-us" xml:lang="en-us" style="font-size:12px;">Forty patients receiving SWL therapy due to kidney stones were
included to study by collecting their blood samples
before and 2 hours after the procedure. </span> </span> </p> <p> </p> <span style="font-size:12px;"> </span> <p class="MsoNormal" style="text-align:justify;line-height:150%;"> <b> <span style="font-size:12px;line-height:150%;font-family:’Times New Roman’, serif;">Results: </span> </b> <span style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;"> <span style="font-size:12px;"> </span> <span lang="en-us" xml:lang="en-us"> <span style="font-size:12px;">It was observed that SWL therapy has
deteriorated the oxidant/antioxidant balance in terms of the oxidants by analyzing
the increase of IL-6 ( </span> <i> <span style="font-size:12px;">P </span> </i> <span style="font-size:12px;"><0,01) and
decrease in PON-1 ( </span> <i> <span style="font-size:12px;">P </span> </i> <span style="font-size:12px;"> = 0.049). There
was no change observed in TAS ( </span> <i> <span style="font-size:12px;">P </span> </i> <span style="font-size:12px;"> =
0.178) and TOS ( </span> <i> <span style="font-size:12px;">P </span> </i> <span style="font-size:12px;"> = 0.175) and OSI ( </span> <i> <span style="font-size:12px;">P </span> </i> <span style="font-size:12px;"> = 0.551) parameters. </span> </span> </span> </p> <p> </p> <span style="font-size:12px;"> </span> <p class="MsoNormal" style="text-align:justify;line-height:150%;"> <b> <span style="font-size:12px;line-height:150%;font-family:’Times New Roman’, serif;">Conclusion: </span> </b> <span lang="en-us" style="font-size:12px;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us">This has shown
that IL-6 and PON-1 may be more sensitive markers of renal injury after SWL in
early period. </span> </p> <p> </p>}, number={3}, publisher={DNT Ortadoğu Yayıncılık A.Ş.}