TY - JOUR T1 - Lidokain, Bupivakain ve Bunların Karışımının Meyve Sineklerinde Ömür Uzunluğu Üzerine Olan Etkisi TT - The Effect of Lidocaine, Bupivacaine and Their Mixture on the Life-span of Fruit Flies AU - Aşkın, Hakan AU - Tükenmez, Ümmügülsüm PY - 2018 DA - December Y2 - 2018 DO - 10.21597/jist.433879 JF - Journal of the Institute of Science and Technology JO - J. Inst. Sci. and Tech. PB - Iğdır Üniversitesi WT - DergiPark SN - 2536-4618 SP - 305 EP - 313 VL - 8 IS - 4 LA - tr AB - Bu çalışmada, farklı özelliklere sahip iki anestezik maddenin Drosophila melanogaster’de (meyve sineği)ömür uzunluğu üzerine etkileri araştırılmıştır. Bu canlıda lokal anestezik maddelerin etkilerine yönelik oldukça azsayıda çalışma mevcuttur. Bu amaçla üçüncü evre larvalara lokal anestezik maddelerin farklı dozları (% 0.0625,% 0.125, % 0.25 ve % 0.5) uygulanmıştır. Kontrol ve uygulama gruplarından elde edilen verilerdebu maddeleremaruz kalan larvalardan gelişen ergin sineklerin ömür uzunluğueğişikliklerine neden olduğu belirlenmiştir. Buçalışmadan elde edilen sonuçlar lidokain ve bupivakain uygulamalarının dişi bireylerde ömür uzunluğunu kontrolegöre arttırdığını ortaya çıkarmıştır (p<0.05). Bu iki lokal anestezik maddenin karışımı ise ortalama ömür uzunluğuve maksimum ortalama ömür uzunluğu üzerine olumlu etki göstermemiştir. KW - Bupivakain KW - Drosophila melanogaster KW - lidokain KW - ömür uzunluğu N2 - In this study, the effects of two anesthetic agents with different properties on the life span ofDrosophila melanogaster (fruit-fly) were investigated. There are very few studies on the effects of local anestheticsin this organism. For this purpose, different doses of the local anesthetic agents (0.0625 %, 0.125 %, 0.25 % and0.5 %) were applied to third stage larvae. 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