TY  - JOUR
T1  - NADİR BİR TROMBOSİTOPENİ SEBEBİ: PRİMERSJÖGREN SENDROMU
TT  - A RARE CAUSE OF THROMBOCYTOPENIA; PRIMARY SJÖGREN’S SYNDROME
AU  - Arda, Pinar
AU  - Erçalık, Cem
AU  - Elik, Hüseyin
AU  - Yılmaz, Figen
AU  - Öncü, Jülide
AU  - Durlanık, Gülgün
AU  - Doğu, Beril
AU  - Kuran, Banu
PY  - 2016
DA  - September
JF  - Sağlık Bilimleri ve Yaşam Dergisi
JO  - SBYD
PB  - İstanbul Arel Üniversitesi
WT  - DergiPark
SN  - 2536-5193
SP  - 24
EP  - 29
VL  - 1
IS  - 1
LA  - tr
AB  - Sjögren Sendromu (SS) başta gözyaşı, tükürük bezi olmak üzere ekzokrin bezlerin lenfosit hücre infiltrasyonu,destrüksiyonu ve disfonksiyonu sonucu gelişen kronik, sistemik ve otoimmün bir hastalıktır(2). Bu inflamasyona B lenfositlerin neden olduğu düşünülmektedir (5). Kuru göz (kseroftalmi,keratokonjonktivitis sikka), kuru ağız (kserostomi), parotis bezi büyümesi ile karakterizedir (2).Anemi, lökopeni, trombositopeni ve lenfoproliferatif hastalıklar SS’ nda ekstraglanduler hematolojiktutulum olarak görülebilir (6). Burada 3 aydır rutin tetkiklerinde izole trombositopeni (33.000/mm3)tespit edilen ve romatolojik hastalık araştırılması için tarafımıza konsülte edilen, kliniğimizce SS tanısıkonulan ve hidroksiklorokin 200 mg 1x1/ gün ve prednizolon 4 mg 1x1/gün tedavisi ile birinciayda trombosit sayısında (195.000/ mm3) düzelme, eklem şikayetlerinde gerileme meydana gelenbir olgu sunulmuştur. Sjögren Sendromunun trombositopeninin nadir bir sebebi olabileceği akıldatutulmalı, ayırıcı tanısında romatolojik değerlendirme yapılmalıdır. 
KW  - Primer Sjögren Sendromu
KW  - Trombositopeni
N2  - Sjögren’s Syndrome (SS) is a chronic, systemic and autoimmune disease which mainly affects lacrimal andsalivary glands via lymphocyte cell infiltration, destruction and dysfunction of the exocrine glands (2).This inflammation is speculated to be caused by B lymphocytes (5). SS is characterised by dry eye (xerophthalmia,keratoconjunctivitis sicca), dry mouth (xerostomia) and hypertrophy of the parotid gland (2).During the course of SS anemia, leucopenia, thrombocytopenia, and lymphoproliferative disorders canoccur as extraglandular hematological involvement (6). Here we present a case with isolated thrombocytopenia(33,000 / mm3) dedected on routine tests since the last 3 months and has been referred to uswith the suspicion of an underlying rheumatologic diesease. The case was diagnosed as primary Sjögren’sSyndrome and hydroxychloroquine 200 mg 1x1 / day and prednisolone 4 mg 1x1 / day was started. Improvementof platelet count (195,000 / mm3) and decline in joint complaints occured in the first month.Sjögren’s syndrome should be kept in mind as a rare cause of thrombocytopenia and rheumatologicalevaluation must be included in differential diagnosis.
CR  - 1. Choung B.S, Yoo W.H, Successful Treatment with intravenous immunglobulin of severe trombocytopenia
complicated in primary Sjogren’s syndrome, Rheumatology International 2012;32(5):1353-
1355. 5
CR  - 2. Hastürk A.B, Sjögren Sendromu, Ataman Ş, Yalçın P. Romatoloji 1.Baskı, 855-870, MN Medikal&Nobel
Tıp Kitap Sarayı, Ankara, 2012. 1
CR  - 3. Jun JW, Bae JK, Lee HS, Kim JH, Ju HW, Choi SW. Treatment with High Dose Dexamethasone of Severe
Thrombocytopenia in Primary Sjögren’s Syndrome. Journal of Rheumatic Diseases 2012;19:6. 9
CR  - 4. Kamath V, Prabhakar B, Veena, Lachikarathman D, Sjogren’s Trombocytopenia, Journal Of The
Assosiation of Physicians of India, 2011;59: 114-115. 4
CR  - 5. Khattri S, Barland P, Primary Sjogren’s syndrome and autoimmune cytopenias: a relation often
overlooked, Bulletin Of The Hospital For Joint Diseases, 2012;70(2):130-132. 2
CR  - 6. Kikawada M, Watanabe D, Kimura A, Hanyu H, Serizawa H, Iwamoto T, Autoimmune hemolytic
anemia in an elderly patient with primary Sjögren’s syndrome, Journal of Internal Medicine, 2005;
44(12):1312-1315. 3
CR  - 7. Ramakrishna R, Chaudhuri K, Sturgess A, Manoharan A. Haematological manifestations of primary
Sjögren’s syndrome: a clinicopathological study. Q J Med 1992;83: 547-54. 7
CR  - 8. Ramos-Casals M, Cervera R, García-Carrasco M, Vidal J, Trejo O, Jiménez S, et al. Cytopenia and
past human parvovirus B19 infection in patients with primary Sjögren’s syndrome. Semin Arthritis
Rheum 2000;29: 373-8. 8
CR  - 9. Ramos-Casals M, Font J, Garcia-Carrasco M, Brito MP, Rosas J, Calvo-Alen J, et al. Primary Sjögren
syndrome: hematologic patterns of disease expression. Medicine (Baltimore) 2002;81: 281-92.
UR  - https://dergipark.org.tr/tr/pub/sbyd/issue//438651
L1  - https://dergipark.org.tr/tr/download/article-file/497351
ER  -