TY - JOUR T1 - Impact of vitamin D on rheumatoid arthritis: real or just patient’s perception? TT - Vitamin D'nin romatoid artrit üzerindeki etkisi: gerçek mi yoksa sadece hasta algısı mı? AU - Çalışkan Uçkun, Aslı AU - Yurdakul, Fatma Gül AU - Kılıçarslan, Ayşegül AU - Başkan, Bedriye AU - Sivas, Filiz AU - Duran, Semra AU - Bodur, Hatice PY - 2018 DA - November DO - 10.25000/acem.440559 JF - Archives of Clinical and Experimental Medicine JO - Arch Clin Exp Med PB - Mustafa HASBAHÇECİ WT - DergiPark SN - 2564-6567 SP - 127 EP - 131 VL - 3 IS - 3 LA - en AB - Aim: In this study, our aims were to identifyvitamin D levels in rheumatoid arthritis (RA) individuals as compared tocontrols and the impact of vitamin D levels on both objective and subjectiveassessments in RA patients. Methods: The current study was a prospectivecase-control study conductedon 108 RA patients and 50 age-gender matched healthy controls. We firstcompared the levels of vitamin D among the RA patients and controls.Demographic and clinical data, parameters of disease activity, inflammatorymarkers, rheumatoid factor and anti-cyclic citrullinated peptide seropositivityand radiological damage scores were recorded in RA patients. These patientswere also demanded to complete RA Quality of Life Questionnaire (RAQoL),fatigue severity scale (FSS) and HealthAssessment Questionnaire (HAQ).Results: D vitamin levels in RA patients weresignificantly lower than healthy controls (p=0.001). Vitamin D deficiency wasdetermined in 73% of the RA patients and 52% of the controls. Vitamin Ddeficiency was not associated with disease activity (p=0.862). There was nosignificant relationship among vitamin D levels and all subjective andobjective assessments (p>0.05 for all ).Conclusion: Vitamin D deficiency was common inRA participants than normal population. However, it was not shown that therewas a significant relationship between vitamin D levels and objective andsubjective assessments of disease, including disease activity, inflammatory markers,rheumatoid factor and anti-cyclic citrullinated peptide seropositivity,radiological damage scores, RAQoL, FSS and HAQ. KW - Rheumatoid Arthritis KW - Vitamin D KW - radiological damage N2 - Amaç: Bu çalışmadaki amaçlarımız, romatoidartrit (RA) hastalarında D vitamini düzeylerini ve D vitamini düzeylerininobjektif ve subjektif değerlendirmelere etkisini belirlemektir.Yöntemler: Bu çalışma, 108 RA hastası ve yaşve cinsiyete göre eşleştirilmiş 50 sağlıklı kontrol üzerinde yapılan bir prospektifolgu-kontrol çalışmasıdır. Öncelikle RA hastaları ve kontroller arasında Dvitamini düzeylerini karşılaştırdık. RA hastalarının demografik ve klinikverileri, hastalık aktivitesi parametreleri, inflamatuvar belirteçleri, romatoidfaktör ve anti-siklik sitrüllenmiş peptid seropozitifliği ve radyolojik hasarskorları kaydedildi. Hastalardan ayrıca RA Yaşam Kalitesi Anketi (RheumatoidArthritis Quality of Life, RAQoL), yorgunluk şiddet ölçeği (Fatigue SeverityScale, FSS) ve Sağlık Değerlendirme Anketi (Health Assessment Questionnaire, HAQ)tamamlamaları istendi.Bulgular: RA hastalarında D vitamin düzeylerisağlıklı kontrollerden anlamlı derecede düşüktü (p=0,001). RA hastalarının %73'ünde ve kontrollerin % 52'sinde D vitamini eksikliği tespit edildi. Dvitamini eksikliği, hastalık aktivitesi ile ilişkili değildi (p=0,862). Dvitamini seviyeleri ile tüm subjektif ve objektif değerlendirmeler arasındaanlamlı bir ilişki bulunamadı (hepsi için p>0,050).Sonuç: Dvitamini eksikliği RA hastalarında normal popülasyona göre daha sıkgörülmektedir. 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