TY  - JOUR
T1  - PREİNVAZİV VE İNVAZİV SERVİKAL LEZYONLARDA HUMAN PAPILLOMA VIRUS (HPV) TİPLERİNİN PREVALANSININ SAPTANMASI
TT  - Prevalence of Human Papillomavirus (HPV) Types in Preinvasive and Invasive Cervical Lesions
AU  - Demirel, Emine Emsal
AU  - Şahin, Hacı Öztürk
PY  - 2018
DA  - November
JF  - Balıkesir Medical Journal
JO  - BMedJ
PB  - Balıkesir Üniversitesi
WT  - DergiPark
SN  - 2564-6664
SP  - 185
EP  - 196
VL  - 2
IS  - 3
LA  - tr
AB  - Servikskanseri insidansı giderek azalmakla beraber hala jinekolojik kanserlerdenölümlerin önemli bir sebebidir. Sitolojik tarama programlarının yaygın olarakkullanılmasıyla özellikle gelişmiş ülkelerde insidans azalmıştır, ancakgelişmekte olan ülkelerde hala önemli bir sağlık sorunu olmaya devametmektedir. Serviksin kolay ulaşılabilir bir organ olması, servikovajinal smearile erken tanı ve tedavinin planlanmasıyla prognoz anlamlı ölçüdeiyileşmektedir. Serviks kanserinde uzun bir preinvaziv sürecin varlığı, taramaprogramlarının önemini göstermektedir. Yapılan epidemiyolojik çalışmalar,serviks kanseri için major risk faktörünün human papilloma virus (HPV) olduğunugöstermiştir. Bu çalışmada; konvansiyonel smear sonucu preinvaziv veya invazivservikal lezyon şüphesi olan hastalarda HPV tiplerinin prevalansının saptanmasıamaçlanmıştır. Çalışmaya preinvaziv veya invaziv servikal lezyon şüphesi olan61 hasta dahil edilmiştir. Hastalardan kolposkopi öncesi alınan HPV numuneleripolimeraz zincir reaksiyonu (PCR) ile değerlendirilmiş, DNA tiplemesiyapılmış,düşük veya yüksek riskli HPV tipleri ile kolposkopik biyopsi sonuçlarıkıyaslanmıştır. Hastalarda HPV tiplerinden en sık HPV 16 saptanmıştır. Bukonuda daha geniş popülasyonlara ulaşılan çalışmalara ihtiyaç duyulmaktadır.
KW  - smear
KW  - HPV
KW  - kolposkopi
N2  - Althoughits incidence is progressively decreasing, cervical cancer is an importantcause of mortality caused by gynecological cancers. With wide utilization ofcytologic screening,programs especially in developed countries, its incidencehas decreased; however, it is still amajor health problem for the developing countries. Due to the easy interventionto the cervix with early diagnosis and treatment onset chance withcervicovaginal smear examination, prognosis of this disease has beensignificantly improved. Long pre-invasive period of the cervical cancershighlights the importance of the screening programs. Previous epidemyologicalstudies showed that the human papilloma virus (HPV) is the major risk factorfor cervical cancer. In this study, we aimed to determine the prevalence of theHPV types in patients who were diagnosed with suspicious pre-invasive or invasivecervical lesions by the conventional smear examination. 61 patients withsuspicious pre-invasive or invasive cervical lesion were enrolled in thisstudy. HPV samples were obtained from patients before colposcopy and thenevaluated with polymerase chain reaction (PCR) and DNA-typing, after these, lowor high-risk HPV types were compared with results of the colposcopic biopsy.Among the HPV types obtained from patients, most common subtype was HPV 16.Further studies with larger populations are required.
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UR  - https://dergipark.org.tr/tr/pub/bmedj/issue//442210
L1  - https://dergipark.org.tr/tr/download/article-file/577322
ER  -