TY  - JOUR
TT  - Alteration of Mean Platelet Volume Levels in Gestational Diabetes Mellitus
AU  - Ademoğlu, Esra
AU  - Tekçe, Hikmet
AU  - Görar, Süheyla
AU  - Kurt, Şule
AU  - Aral, Yalçın
PY  - 2016
DA  - December
JF  - Kocaeli Tıp Dergisi
PB  - Kocaeli Derince Eğitim ve Araştırma Hastanesi
WT  - DergiPark
SN  - 2147-0758
SP  - 12
EP  - 17
VL  - 5
IS  - 3
KW  - Ortalama Trombosit Hacmi (OTH)
KW  - Gestasyonel Diabetes Mellitus
KW  - Trombosit
N2  - INTRODUCTION: MPV (mean platelet volume) is a laboratory parameter which shows the average size of platelets. In the literature, MPV has been reported to decrease in some diseases associated with inflammation and considered one indicator of inflammation. The main objective of this study is to investigate the MPV in gestational diabetes mellitus (GDM) as a clinical condition characterized with increased proinflammatory and proatherogenic risk. In addition, the correlation of MPV with various hematologic and biochemical parameters have also been assessed, and whether MPV is a risk factor for the development of GDM has been examined.METHODS: Datas of 43 women newly diagnosed with gestational diabetes mellitus (GDM) at 24-28 weeks of gestation and 35 healthy pregant women were analyzed.RESULTS: Platelet counts were found to be significantly higher in gestational diabetes group compared to controls (p=0.013) while MPV was significantly found to be lower(0.010). A negative correlation was found between MPV and platelet count in bivariate analysis (p=0.001, r=-0.88). Low MPV (p= 0.027) as well as fasting blood glucose (p=0.008) and BMI (p=0.04), were found to be independent predictors fort he development of GDM.DISCUSSION AND CONCLUSION: MPV was found to be lower in GDM group compared to healty pregnant individuals and was determined to be an independent risk factor for development of gestational diabetes mellitus.
UR  - https://dergipark.org.tr/tr/pub/kotder/issue//448018
L1  - https://dergipark.org.tr/tr/download/article-file/514019
ER  -