TY - JOUR T1 - Prevalence of Vitamin D Deficiency in Healthy Adults AU - Paydaş Hataysal, Esra AU - Saraçlıgil, Beyza AU - Abuşoğlu, Sedat AU - Ünlü, Ali AU - Vatansev, Hüsamettin PY - 2019 DA - September DO - 10.21763/tjfmpc.451729 JF - Turkish Journal of Family Medicine and Primary Care JO - TJFMPC PB - Aile Hekimliği Akademisi Derneği WT - DergiPark SN - 1307-2048 SP - 335 EP - 341 VL - 13 IS - 3 LA - en AB - Objectives: Vitamin D is awell-known hormone and important for many metabolic pathways and differenthealth outcomes. The physiology of vitamin D is very complex. Multiple factorslike ethnicity, age, sex, diseases, and medication influence vitamin Dconcentrations. In this study, our aim was to determine the prevalenceof vitamin D deficiency among adults inTurkey.Material-methods: The 25(OH) vitD3test results of 2007 patients admitted to Selçuk University Medicine Faculty hospitalbetween the years of 2015 and 2016 were analyzed, retrospectively. Patientsusing any vitamin D consisting drug, having chronic disease and inflammatorydisorders were excluded. Vitamin D levels were measured by achromatographic method (LC/MS/MS) with API3200 which is the gold standard tomeasure 25(OH)D3. Results: Ourresults show that the prevalence of vitamin D deficiency isabout 67.9% in our society. The meanvalue of vitamin D was 16,87 ng/mL and females had significantly lower 25(OH)D3levels compared to males (p<0.001).The 25(OH)D3 levels werehigher in summer and in fall than in winter and spring. (p<0.001) Conclusıons: The results indicate thatvitamin D deficiency is prevalent in this study population despite highlevels of sunshine and UV radiation throughout the year.Preventive treatments should beplanned.Amaç: D vitamini,birçok metabolik yolakta rol alan ve bazı hastalıklarla ilişkili olan birhormondur. Vitamin D fizyolojisi çok karmaşıktır. Etnik köken, yaş, cinsiyet, hastalıklar veilaç kullanımı vitamin D konsantrasyonunu etkilemektedir. Bu çalışmada amacımızTürkiye’de sağlıklı erişkinlerde vitamin D eksikliği sıklığını belirlemekti. Yöntem: 2015-2016yılları arasında Selçuk Üniversitesi Tıp Fakültesi Hastanesi'ne başvuran 2007hastanın 25(OH)D3 test sonuçları retrospektif olarak incelendi. VitaminD içeren ilaç kullanan, kronik hastalık veya enflamatuar hastalıkları olanhastalar çalışma dışı bırakılmıştır. D vitamini seviyeleri, 25(OH)D3ölçmek için altın standart olan kromatografik yöntemle (LC / MS / MS) API3200cihazı ile ölçülmüştür. Sonuçlar: Bulgularımız,çalışma popülasyonumuzda D vitamini eksikliği prevalansının yaklaşık %67,9olduğunu göstermektedir. D vitamini ortalama değeri 16,87 ng/mL idi vekadınlarda 25(OH)D3 seviyeleri, erkeklere göre anlamlı derecede düşüktü (p<0,001). Yaz ve sonbahar mevsiminde 25 (OH) D3 seviyeleri, kış ve ilkbaharmevsimine göre daha yüksekti.(p <0.001) Tartışma: Sonuçlarımızyıl boyunca yüksek düzeyde güneş ve UV ışığına rağmen, D vitamini eksikliğininpopülasyonumuzda yaygın olduğunu göstermektedir. Önleyici tedavilerplanlanmalıdır. KW - Vitamin D deficiency KW - LC/MS/MS KW - prevalence CR - 1. Heaney RP, Dowell MS, Hale CA, Bendich A. Calcium absorption varies within the reference range for serum 25-hydroxyvitamin D. J Am Coll Nutr 2003;22:142-146. CR - 2. Wacker M, Holick MF. Sunlight and vitamin D: a global perspective for health. Dermato-Endocrinol. 2013;5(1):51–108. CR - 3. Holick MF. The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention. Rev Endocr Metab Disord (2017) 18:153–165 DOI 10.1007/s11154-017-9424-1 CR - 4. Altieri B, Muscogiuri G, Barrea L, Mathieu C, Vallone CV, Mascitelli L et al. Rev Endocr Metab Disord. Does vitamin D play a role in autoimmune endocrine disorders? 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