@article{article_451871, title={Antibacterial Activity of DMSO Extracts of Selected Plants Against Antibiotic Resistant Clinical Isolates}, journal={Erzincan University Journal of Science and Technology}, volume={12}, pages={576–584}, year={2019}, DOI={10.18185/erzifbed.451871}, author={Saral, Ayşegül and Kardil, Uğur and Özad Düzgün, Azer}, keywords={Antibiotic Resistance,Pseudomonas aeruginosa,Escherichia coli,Minimum Inhibitory Concentration,Plant Extract}, abstract={<p class="MsoNormal" style="margin-top:6pt;margin-right:0cm;margin-bottom:6pt;margin-left:0cm;line-height:normal;"> <span style="font-size:10pt;">In this study, we aimed to find out new herbal materials
that are able to inhibit the growth of the <i>P.
aeruginosa </i> and <i>E.coli </i> clinical isolates
that has antibiotic resistance. Clinical isolates used in this research are <i>E. coli </i> (n=1) and <i>P.aeruginosa </i> (n=1). Antibiotic susceptibility profiles of <i>E. coli </i> and <i>P. aeruginosa </i> were determined using e-test. Plants were collected
in Trabzon region of Turkey are <i>Calendula officinalis </i>, <i>Hypericum perforatum </i> and <i>Glycyrrhiza glabra. </i> DMSO were used as
solvent and solid-liquid extraction was employed. Micro-dilution method was
preferred fo the determination of the minimum inhibitory concentration (MIC). MIC
results were obtained through observation of turbidities. According to E-test
results, while <i>P. aeruginosa </i> was
resistant to piperacillin, piperacillin/tazobactam, meropenem and ceftazidime, <i>E. coli </i> was resistant to piperacillin,
cefotaxime and ceftazidime. DMSO extract of <i>Calendula
officinalis </i> showed very strong activity against PA1 with the best MIC (5
mg/mL).  DMSO extract of three plant had
lower MIC values (5-10 mg/ml) for EC1 and PA1 than ampicillin. In future
studies antibacterial activity of different solvents extracts of these plants
and other plants against antibiotic resistant clinical isolates will be
examined. Natural products from plants are promising in fighting with
antibiotic-resistant bacteria. <b> </b> </span> </p> <p> <b> </b> </p> <b> </b>}, number={2}, publisher={Erzincan Binali Yıldırım Üniversitesi}