@article{article_453321, title={Hepatic Fibrosis in Four German Shepherd Dogs Idiopathic, Genetic Predisposition or a Familial Relationship?}, journal={Kocatepe Veterinary Journal}, volume={11}, pages={501–507}, year={2018}, DOI={10.30607/kvj.453321}, author={Alihosseini, Hadi and Çolakoğlu, Ekrem Çağatay and Haydardedeoğlu, Ali Evren and Kurtdede, Arif}, keywords={Fibroz,idiyopatik,karaciğer,köpek,genetic}, abstract={<p class="MsoNormal" style="text-align:justify;"> <span style="font-size:11pt;font-family:Garamond, serif;">Idiopathic hepatic
fibrosis (İHF) is an inevitable result of chronic liver disease progressing to
cirrhosis. Idiopathic Hepatic fibrosis is characterized as congenital or
juvenile form in German Shepherd Dogs. However, few data have been published on
the incidence and prevalence of IHF in canine species. The case report presented
here describes idiopathic hepatic fibrosis in four neutered German Shephered
dogs </span> <span style="font-size:11pt;font-family:Garamond, serif;">with a
familial relationship. </span> <span style="font-size:11pt;font-family:Garamond, serif;">The main clinical complaints were
refractory ascites, variable appetite and progressive weight loss. Hepatic
fibrosis was confirmed with diagnostic applications and liver biopsy.
Nevertheless, all dogs died in spite of supportive and aggressive treatment.
Necropsy was performed in the dogs according to written owner consent. In
conclusion, the cases presented here reflect the congenital condition of
idiopathic hepatic fibrosis in young German Shepherd Dogs with
histopathological evidence. However, there was evidence of familial
relationship in the cases presented here.  </span> </p> <p> </p> <p> </p>}, number={4}, publisher={Afyon Kocatepe Üniversitesi}