TY  - JOUR
T1  - Türk Atletlerde D Vitamini Reseptör Geni Fok1 (rs2228570) ve Bsm1 (rs1544410) Polimorfizmlerinin Analizi
TT  - Analysis of Vitamin D Receptor Fok1 (rs2228570) and Bsm1 (rs1544410) Polymorphism in Turkish Athletes
AU  - Ulucan, Korkut
AU  - Eken, Basak Funda
AU  - Gezmiş, Hazal
AU  - Sercan, Canan
AU  - Kapıcı, Sezgin
AU  - Chouseın, Özlem Moufti
AU  - Kıraç, Deniz
AU  - Akyüz, Serap
PY  - 2018
DA  - December
Y2  - 2018
DO  - 10.38079/igusabder.453412
JF  - İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi
JO  - IGUSABDER
PB  - İstanbul Gelişim Üniversitesi
WT  - DergiPark
SN  - 2536-4499
SP  - 561
EP  - 572
IS  - 6
LA  - tr
AB  - Amaç: D vitamini kasların gelişmesinde,kasılmasında ve rejenerasyonunda görev alan önemli bir moleküldür. Çalışmamızdaprofesyonel Türk atletlerde D vitamin reseptör (VDR) Fok1 (rs 2228570) ve Bsm1(rs1544410) polimorfizmlerinin dağılımını araştırmayı amaçladık.Yöntem: Çalışmamıza 13 kadın ve 14 erkekatlet olmak üzere 27 sporcu katılmıştır. DNA izolasyonları sonrasında Dvitamini reseptörü polimorfizmleri gerçek zamanlı PZR (RT-PCR) metodu ilesaptanmıştır. Bulgular: Fok1 polimorfizmi açısından atletlerin 12’si CC, 5’i CT ve 10’u iseTT genotipindedir. Kadın atletlerin 6’sı CC, 2’si CT ve 5’i ise TT genotipindebulunmuştur. Erkek atletlerde 6 sporcu CC, 3 sporcu CT ve 5 sporcu ise TTgenotipindedir. Bsm1 polimorfizmi için 9 atlet AA, 14'ü AG, 4’ü ise GG genotipindedir.Kadın atletlerin 3’ü AA, 8’i AG ve 2’si GG genotipindedir. Erkek atletlerin6’sı AA, 6’sı AG ve 2’si GG genotipinde saptanmıştır. Sonuç:Çalışma grubumuzda Fok1 polimorfizmiiçin CC genotipi ve C allelinin, Bsm1 içindeAG genotipinin ve A allelinin baskın olduğu gözlenmiştir. Bu çalışmanın VDR geninin atletik performansaetkisinin araştırılması için yapılacak yeni çalışmalar için referans olacağınıdüşünmekteyiz.
KW  - D vitamini reseptörü
KW  - sporcular
KW  - spor genetiği
KW  - polimorfizm
N2  - Aim: Vitamin D is an important molecule responsible for thedevelopment, contraction and regeneration of muscles. In this study, we aimedto research the distribution of vitamin D receptor (VDR) Fok1 (rs 2228570) andBsm1 (rs1544410) polymorphisms in professional Turkish athletes.Method: A total 27 athletes including 13 female and 14 maleathletes participated in the study. Following DNA isolation, polymorphisms ofVDR were determined by real-time PCR (RT-PCR). Findings: 12 of the athletes have CC, 5 of them have CT and 10of them have TT genotypes in terms of Fok1 polymorphism. 6 female athletes weredetermined as CC, 2 of them as CT and 5 of them as TT genotype. 6 male athleteswere found as CC, 3 of them as CT and 5 of them as TT genotype. For Bsm1polymorphism, 9 athletes have AA, 14 of athletes have AG and 4 of them have GGgenotypes. 3 of the female athletes have AA, 8 of them have AG and 2 of themhave GG genotypes. 6 of male athletes have AA, 6 of them have AG and 2 of themhave GG genotypes. Conclusion:Inour study, it was observed that CC genotype and C allele for Fok1 polymorphismwere dominant of AG genotype and A allele in Bsm 1. We believe that this studywill be a reference for new studies to research the effect of VDR gene onathletic performance.
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UR  - https://doi.org/10.38079/igusabder.453412
L1  - https://dergipark.org.tr/tr/download/article-file/614467
ER  -