@article{article_454933, title={Biological evaluation of 2,5-dimethyl-1,4-benzoquinone biotransformation metabolite}, journal={Natural Volatiles and Essential Oils}, volume={4}, pages={14–17}, year={2017}, author={Ağalar Hale Gamze and İşcan, Gökalp and Noma, Yoshiaki and Atlı, Özlem and Demirci, Fatih and Kırımer, Neşe}, keywords={Benzoquinone, microbial biotransformation, biological activity}, abstract={<div class="page" title="Page 1"> <div class="layoutArea"> <div class="column"> <p> <span style="font-size:14px;font-family:Calibri;">The substrate of this study, 2,5-dimethyl-1,4-benzoquinone (DMBQ), is one of the naturally occurring quinones which is found in
insects as a defence metabolite. In the present study, DMBQ was biotransformed by using the micro-fungus </span> <span style="font-size:14px;">Corynespora cassicola </span> <span style="font-size:14px;font-family:Calibri;">.
The transformation metabolite was initially screened by TLC and GC-MS, then further characterized by NMR ( </span> <span style="font-size:14px;font-family:Calibri;vertical-align:3pt;">13 </span> <span style="font-size:14px;font-family:Calibri;">C- and </span> <span style="font-size:14px;font-family:Calibri;vertical-align:3pt;">1 </span> <span style="font-size:14px;font-family:Calibri;">H-NMR)
spectroscopic techniques and was </span> <span style="font-size:14px;font-family:Calibri;">identified as ‘2,5 </span> <span style="font-size:14px;font-family:Calibri;">-dimethyl 1,4-benzene </span> <span style="font-size:14px;font-family:Calibri;">diol’. </span> <span style="font-size:14px;font-family:Calibri;">In addition, both the substrate and metabolite was
evaluated for the </span> <span style="font-size:14px;">in vitro </span> <span style="font-size:14px;font-family:Calibri;">anticandidal, and antioxidant properties along with XTT-cytotoxicity. </span> </p> <span style="font-size:14px;"> </span> </div> <span style="font-size:14px;"> </span> </div> <span style="font-size:14px;"> </span> </div> <p> <br /> </p>}, number={1}, publisher={Badebio Biotechnology Ltd.}