TY - JOUR T1 - Exogenous Lipoid Pneumonia Due To Intramuscular Injection of Synthol in a Bodybuilder TT - Vücut Geliştiricide İntramuskuler Synthol Enjeksiyonuna Bağlı Lipoid Pnömoni AU - Öcal, Nesrin AU - Günal, Armağan AU - Arslan, Yakup AU - Kaçmaz, Berat AU - Coşkun, Ali AU - Karan, Bahadır Can AU - Doğan, Deniz AU - Taşçı, Cantürk AU - Uçar, Ergün PY - 2019 DA - March JF - Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi JO - MMJ PB - Muğla Sıtkı Koçman Üniversitesi WT - DergiPark SN - 2148-8118 SP - 48 EP - 51 VL - 6 IS - 1 LA - en AB - We report a case of chronic exogenous lipoidpneumonia that developed due to recurrent intramuscular use of “Synthol”, asynthetic oil derivative, for muscle filling. 40-year-old man, who had usedSynthol to enlarge his pectoral muscles, was admitted to the chest diseasespolyclinic with shortness of breath progressing within a year. On computerizedtomography of thorax there were reticulations and septal thickenings consistentwith interstitial lung disease. The patient underwent bronchoscopy.Bronchoalveolar lavage and transbronchial biopsy (TBB) were performed. In thehistopathologic study of TBB, intraalveolar and interstitial fatty macrophages,giant cells around fat particles and extracellular fat particles were observedand the specimen was reported as "lipoid pneumonia". According to ourknowledge, exogenous lipoid pneumonia due to intramuscular use of Synthol hasnot been reported heretofore and this is the first case in the literature. KW - Bodybuilder KW - Lipoid Pneumonia KW - Synthetic Oil KW - Synthol N2 - Bu makalede kas dolgusu amacıyla sentetik biryağ türevi olan “Synthol” un tekrarlayan intramuskuler kullanımı nedeniylegelişen kronik eksojen lipoid pnömoni olgusu sunulmuştur. Göğüs kaslarınıbüyütmek için Synthol kullanan 40 yaşında erkek hasta, bir yıl içinde ilerleyennefes darlığı ile birlikte polikliniğimize başvurdu. Toraks tomografisindeinterstisyel akciğer hastalığı ile uyumlu retikülasyonlar ve septalkalınlaşmalar izlenmekteydi. Hastaya bronkoskopi yapıldı. Bronkoalveolar lavaj vetransbronşiyal biyopsi (TBB) alındı. TBB'nin histopatolojik incelemesinde,intraalveoler ve interstisyel yağlı makrofajlar, yağ partikülleri etrafındakidev hücreler ve ekstraselüler yağ partikülleri gözlendi. Örnek “lipoid pnömoni”olarak raporlandı. Bizim bilgimize göre Synthol'un intramusküler kullanımınabağlı ekzojen lipoid pnömonisi şimdiye kadar bildirilmemiştir ve olgumuzliteratürdeki ilk olgudur. CR - 1. Gondouin A, Manzoni PH, Ranfaing E, et al. Exogenous lipid pneumonia: a retrospective multicentric study of 44 cases in France. Eur Respir J. 1996;9:1463–9. CR - 2. Cherrez Ojeda I, Calderon JC, Guevara J, Cabrera D, Calero E, Cherrez A. Exogenous lipid pneumonia related to long-term use of Vicks VapoRub by an adult patient: a case report. BMC Ear, Nose Throat Disord. 2016;16:11. CR - 3. Betancourt SL, Martinez-Jimenez S, Rossi SE, Truong MT, Carrillo J, Erasmus JJ.Lipoid pneumonia:spectrum of clinical and radiologic manifestations. Am J Roentgenol. 2010;194:103-9. CR - 4. Laughlin GF. Studies of pneumonia following injections of oil. Am J Pathol. 1925;1:407–14. CR - 5. Marchiori E, Zanetti G, Mano CM, Irion KL, Daltro PA, Hochhegger B. Lipoid pneumonia in 53 patients after aspiration of mineral oil: comparison of high-resolution computed tomography findings in adults and children. J Comput Assist Tomogr. 2010; 34(1): 9-12. CR - 6. Rahaghi F, Varasteh A, Memarpour R, Tashtoush B. Teppanyaki/Hibachi Pneumonitis: An Exotic Cause of Exogenous Lipoid Pneumonia. Case Rep Pulmonol. 2016; 2016: 1035601. CR - 7. Hotta T, Tsubata Y, Okimoto T, Hoshino T, Hamaguchi S, Isobe T. Exogenous lipoid pneumonia caused by herbicide inhalation. Respirol Case Rep. 2016;4(5): e00172. CR - 8. Yasui H, Yokomura K, Suda T. A severe case of acute exogenous lipoid pneumonia treated with systemic corticosteroid. Respir Med Case Rep. 2016;17: 64–7. CR - 9. Russell M, Storck A, Ainslie M. Acute respiratory distress following intravenous injection of an oil-steroid solution. Can Respir J. 2011;18(4): 59–61. CR - 10. Fumo G, Ferreli C, Murgia S, Galletti R, Pau M. A serious complication due to liquid silicone injection in the legs for cosmetic purpose. Clin Ter. 2013;164(5):377-9. CR - 11. Gersuny R. Ueber eine subcutyane Prothese. Z Heilk. 1900;30:1–5. CR - 12. Pupka A, Sikora J, Mauricz J, Cios D, Plonek T. The usage of synthol in the body building. Polim Med. 2009;39:63–5. CR - 13. Ghandourah S, Hofer MJ, Kießling A, El-Zayat B, Schofer MD. Painful muscle fibrosis following synthol injections in a bodybuilder: a case report. J Med Case Rep. 2012;6:248. CR - 14. https://www.pneumotox.com/drug/view/1171/synthol UR - https://dergipark.org.tr/tr/pub/muskutd/issue//456531 L1 - https://dergipark.org.tr/tr/download/article-file/674954 ER -