@article{article_456990, title={Determination of polymyxin B, minocycline, colistin and phosphomycin susceptibilities in Acinetobacter baumannii strains showing carbapenem resistant multidrug resistance phenotype}, journal={Journal of Health Sciences and Medicine}, volume={2}, pages={49–53}, year={2019}, DOI={10.32322/jhsm.456990}, author={Cesur, Salih and Kınıklı, Sami and Cesur, Salih and Yücel, Mihriban and Ataman Hatipoğlu, Çiğdem and Dinç, Bedia}, keywords={Acinetobacter baumannii,polimiksin B,minosiklin,kolistin,fosfomisin,duyarlılık,çoklu ilaç direnci}, abstract={<p class="MsoNormal" style="margin-bottom:.0001pt;text-align:justify;line-height:200%;"> <b> <span style="font-family:’Times New Roman’, serif;">Objective: </span> </b> <span style="font-family:’Times New Roman’, serif;"> In this study, the sensitivity of minocycline, polymyxin B, cholestin and phosphomycin to carbapenem resistant multiresistant <i>Acinetobacter baumannii </i>( <i>A. baumannii </i>) strains (resistant to three or more antibiotic groups) isolated from patients in Ankara Training and Research Hospital It was aimed. </span> </p> <p> </p> <p class="MsoNormal" style="margin-bottom:.0001pt;text-align:justify;line-height:200%;"> <b> <span style="font-family:’Times New Roman’, serif;">Material and Method: </span> </b> <span style="font-family:’Times New Roman’, serif;"> Eighty nosocomial <i>A. baumanii </i> strains with a carbapenem resistant multidrug resistance phenotype were included in the study. Sensitivities of minocycline, polymyxin B and phosphomycin were determined by disc diffusion test and colistin susceptibility test by disk diffusion and E-test methods. </span> </p> <p> </p> <p class="MsoNormal" style="margin-bottom:.0001pt;text-align:justify;line-height:200%;"> <b> <span style="font-family:’Times New Roman’, serif;">Results: </span> </b> <span style="font-family:’Times New Roman’, serif;"> Eighty (100%) polymyxin B, 75 (93,75%) minocycline sensitive and 4 (5%) medium susceptible to 80 carbapenem resistant A.baumannii strains were evaluated by disc diffusion method. 75 (93.5%) were sensitive to colistin, 5 (6.25%) were moderately sensitive to colistin and 2 (2.5%) were sensitive to phosphomycin. By e-test, all 80 strains (100%) were detected as susceptible to colistin. The MIC range for colistin was 0.125-1.5 μg / ml, the MIC 50 value was 025 μg / ml (the MIC range was found to be 0.5 μg / ml). </span> </p> <p> </p> <p class="MsoNormal" style="margin-bottom:.0001pt;text-align:justify;line-height:200%;"> </p> <p class="MsoNormal" style="margin-bottom:.0001pt;text-align:justify;line-height:200%;"> <b> <span style="font-family:’Times New Roman’, serif;">Conclusion: </span> </b> <span style="font-family:’Times New Roman’, serif;"> Polymyxin B and minocycline could be used in therapy because phosphomycin B and susceptibility rates were high in empirical treatment of carbamazepine resistant multispecific A.baumannii strains in our hospital. Phosphomycin could not be used in treatment because of high resistance rate. </span> </p> <p> </p> <p> </p>}, number={2}, publisher={MediHealth Academy Yayıncılık}