TY - JOUR T1 - Gastrointestinal findings in children with Down syndrome: Is there an early sign for celiac disease? TT - Down sendromlu çocuklarda gastrointestinal bulgular: Çölyak hastalığı için erken bir belirti var mı? AU - Kocamaz, Halil AU - Işıkay, Sedat PY - 2018 DA - November DO - 10.25000/acem.457551 JF - Archives of Clinical and Experimental Medicine JO - Arch Clin Exp Med PB - Mustafa HASBAHÇECİ WT - DergiPark SN - 2564-6567 SP - 195 EP - 197 VL - 3 IS - 3 LA - en AB - Aim: To investigate the prevalence of celiac disease(CD) among children with Down’s syndrome (DS) and its association withgastrointestinal symptoms and other accompanying diseases. Methods: The study was consisted of regular trisomy 21patients who were under follow-up in our department. The age, gender,gastrointestinal symptoms (abdominal pain, constipation, diarrhea, abdominaldistension, vomiting, flatulence, and unsatisfactory weight gain/weight loss)and accompanying diseases were recorded. Anti-tissue transglutaminase(anti-tTG) immunoglobulin A (Ig A) levels were analyzed in all cases.Serologically positive patients were referred to a pediatric gastroenterologistfor intestinal biopsy. Results: Totally 98 children with a mean age of 3.2±2.81years (range: 2-13 years) diagnosed with the DS were included in this study.Among study participants, 46 (46.9%) were female. Among study participants, 3(3.1%) had positive anti-tTG IgA results and endoscopic biopsies revealed thediagnosis of Marsh type 3b CD in all of them. In correlation analysis,hypothyroidism (p=0.03) and presence of diarrhea (p=0.04) significantlycorrelated with the CD presence among children with the DS. Diarrhea increasedthe risk for 1.50 times (0.67-3.34) while hypothyroidism increased the risk for2.75 times (0.55-13.67) among patients with DS. Conclusion: Clinicians should be aware of an increasedprevalence of CD among patients with DS especially in children with diarrheaand/or hypothyroidism. KW - Celiac disease KW - children KW - Down syndrome N2 - Amaç: Down sendromlu (DS) çocuklarda çölyakhastalığının (ÇH) sıklığını ve gastrointestinal semptomlar ve eşlik eden diğerhastalıklarla birlikteliğini saptamak. Yöntemler: Çalışmaya kliniğimizde takip edilen regülertrizomi 21 olan hastalar alındı. Yaş, cinsiyet, gastrointestinal semptomlar(karın ağrısı, kabızlık, diyare, abdominal distansiyon, kusma, şişkinlik vekilo alımı / kilo kaybı) ve eşlik eden ek hastalıklar kaydedildi. Tüm olgulardaanti-doku transglutaminaz (anti-tTG) immünoglobulin A (IgA) düzeyleri analizedildi. Serolojik olarak pozitif hastalar, bağırsak biyopsisi çocukgastroenterolojisi tarafından yapıldı. Bulgular: Çalışmaya yaş ortalaması 3,2 ± 2,81 yıl(2-13 yıl) olan 98 çocuk alındı. Hastaların 46 (% 46,9) kızdı. Hastaların3'ünde (% 3,1) anti-tTG IgA pozitifliği vardı ve endoskopik biyopsilerinhepsinde Marsh tip 3b ÇH tanısı saptandı. 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UR - https://doi.org/10.25000/acem.457551 L1 - https://dergipark.org.tr/tr/download/article-file/586222 ER -