TY  - JOUR
T1  - Depression in Rheumatoid Arthritis: Association with Quality of Life, Function and Disease Activity
TT  - Romatoid Artritte Depresyon: Yaşam Kalitesi, Fonksiyon ve Hastalık Aktivitesi ile İlişkisi
AU  - Yurdakul, Fatma Gül
AU  - Garip Çimen, Yeşim
AU  - Kılıçarslan, Ayşegül
AU  - Çalışkan Uçkun, Aslı
AU  - Bodur, Hatice
PY  - 2018
DA  - September
DO  - 10.17098/amj.461385
JF  - Ankara Medical Journal
JO  - Ankara Med J
PB  - Ankara Yıldırım Beyazıt Üniversitesi
WT  - DergiPark
SN  - 2148-4570
SP  - 337
EP  - 344
VL  - 18
IS  - 3
LA  - en
AB  - Objectives: The aim of our study is to evaluate thedepression rate in patients with rheumatoid arthritis (RA) and its associationwith pain, disease activity, functional status, and various health relatedquality of life (HRQoL) domains in terms of functional status, vitality, socialand emotional functioning.Materials and Methods: A total of 90 RA patients and 50 sex andage matched controls were included in the study. Demographic characteristics,erythrocyte sedimentation rates, C‐reactive protein, tender and swollen jointcount, patient and physician global assessment of disease activity wererecorded. Disease Activity Score‐28 (DAS28) was used for measuring diseaseactivity. The severity of pain was determined by using 10 cm Visual AnalogScale‐Pain (VAS‐pain). HRQoL was evaluated by using Short Form 36 (SF 36). HAQ(Health Assessment Questionnaire) was used for evaluation of the functionalstatus. Depression was evaluated by using Beck Depression Scale (BDS).Results: Mean age was 54.51±12.54 in RA (75 women,15 men) group and 51.94±9.69 in the control group (41 women, 9 men). Mean VAS‐painwas 55.85±26.24; HAQ was 1.27±0.81 and DAS28 was 5.04 ±2.44 in RA patients. Themean BDS was 19.67±13.11 in RA group and 6.64±6.73 in the control group. RApatients scored significantly higher in BDS when compared with the controls(p<0.001). BDS was linearly related with DAS28 and VAS‐pain at a high leveland negatively correlated with physical function, physical role, bodily pain,general health, vitality, mental health, social functioning and emotional rolesubgroups of SF36 (p<0.001). There was no statistically significant relationbetween BDS and HAQ (p=0.431)Conclusion: Depression is common in the patients withRA and associated with disease activity and pain. It negatively affects HRQoLin terms of vitality, and physical, social and emotional functioning.
KW  - Arthritis
KW  - rheumatoid
KW  - depression
KW  - quality of life
N2  - Amaç: Çalışmamızın amacı romatoid artritli (RA)hastalarda ağrı, hastalık aktivitesi, fonksiyonel durum ve vitalite,fonksiyonellik, sosyal ve duygusal işlevsellik gibi sağlıkla ilişkili yaşamkalitesi (HRQoL) alanları arasındaki ilişkiyi değerlendirmektir.Materyal ve Metot: Çalışmayatoplam 90 RA hastası ve 50 cinsiyet ve yaş uyumlu kontrol dahil edildi. Demografiközellikler, eritrosit sedimantasyon oranları, C‐reaktif protein, hassas ve şişeklem sayısı, hasta ve hekimin global değerlendirmesi kaydedildi. Hastalıkaktivitesini ölçmek için Hastalık Aktivite Skoru‐28 (DAS28) kullanıldı. Ağrınınşiddeti, 10 cm Görsel Analog Skala‐Ağrı (VAS‐ağrı) kullanılarak belirlendi.HRQoL, Kısa Form 36 (SF 36) kullanılarak değerlendirildi. Fonksiyonel durumun değerlendirilmesiiçin HAQ (Sağlık Değerlendirme Anketi) kullanıldı. Depresyon, Beck Depresyon Ölçeği(BDS) kullanılarak değerlendirildi.Bulgular: Yaş ortalaması RA'da (54kadın, 15 erkek) 54,51 ± 12,54; kontrol grubunda (41 kadın, 9 erkek) 51,94 ±9,69 idi. RA'lı hastalarda ortalama VAS 55,85 ± 26,24 idi; HAQ 1,27 ± 0,81,DAS28 ise 5,04 ± 2,44 idi. RA grubunda ortalama BDS 19,67 ± 13,11 ve kontrolgrubunda 6,64 ± 6,73 idi. RA hastalar kontrol grubu ile karşılaştırıldığında,BDS'de anlamlı olarak daha yüksek puan aldı (p <0,001). BDS ile DAS28 ve VAS‐ağrıarasında doğrusal ilişki vardı ve SF36'nın fiziksel işlev, fiziksel rol, vücutağrısı, genel sağlık, vitalite, zihinsel sağlık, sosyal işlevsellik ve duygusalrol alt grupları ile negatif korelasyon gösterdi (p <0,001). BDS ve HAQ arasındaistatistiksel olarak anlamlı bir ilişki bulunmadı (p=0,431).Sonuç: RA'lı hastalardadepresyon yaygındır ve hastalık aktivitesi ve ağrı ile ilişkilidir. Depresyon, vitalitefiziksel, sosyal ve duygusal işlevler açısından HRQoL'yi olumsuz yöndeetkilemektedir.
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UR  - https://doi.org/10.17098/amj.461385
L1  - https://dergipark.org.tr/tr/download/article-file/538165
ER  -