TY  - JOUR
T1  - Akromegalinin Nadir Bir Prezentasyonu: Diyabetik Ketoasidoz
TT  - An Unusual Presentation Of Acromegaly: Diabetic Ketoacidosis
AU  - Beyan, Esin
AU  - Çelik, Nilüfer Merve
AU  - Çelik, Yakup
AU  - Dal, Kürşat
PY  - 2019
DA  - July
JF  - Akademik Araştırma Tıp Dergisi
JO  - AATD
PB  - Keçiören Eğitim ve Araştırma Hastanesi
WT  - DergiPark
SN  - 2528-9152
SP  - 22
EP  - 25
VL  - 3
IS  - 1
LA  - tr
AB  - Akromegalide glukoz metabolizması anormallikleri sık görüldüğü halde,diyabetik ketoasidoz nadir bir komplikasyon olarak tanımlanmıştır. Bu makalede42 yaşında diyabetik ketoasidozlu bir olgu sunulmaktadır. Metabolik bozuklukiçin bir sebep bulunamayan, insülin ihtiyacı çok yüksek olan olguda laboratuvarçalışmaları ile akromegali saptandı. Hipofiz adenomuna yönelik cerrahi sonrasıinsülin ihtiyacı belirgin olarak azaldı. Olgumuz nadir bir durum olan diyabetikketoasidoz ile akromegali birlikteliğini göstermektedir. Akromegali yüksek dozinsülin ihtiyacının ayırıcı tanısında göz önünde bulundurulmalıdır.
KW  - Akromegali
KW  - . Diabetes mellitus
KW  - Diyabetik ketoasidoz
N2  - Although the abnormalities of glucose metabolism were common inacromegaly, diabetic ketoacidosis was described as a rare complication. A caseof 42-year-old woman who had diabetic ketoacidosis in this case report.Laboratory studies were confirmed the diagnosis of acromegaly in patient whichhad no specific cause for metabolic derangement and insulin need was very high.After the pituitary adenoma removed surgically, insulin need was markedlyreduced. This case shows the rare association between diabetic ketoacidosis andacromegaly. Acromegaly should be considered in the differential diagnosis ofhigh dose insulin needed.
CR  - Chanson P, Salenave S, Kamenicky P, Cazabat L, Young J. Pituitary tumours: acromegaly. Best Pract Res Clin Endocrinol Metab 2009; 23: 555-74.
CR  - Yoshida N, Goto H, Suzuki H, et al. Ketoacidosis as the initial clinical condition in nine patients with acromegaly: a review of 860 cases at a single institute. Eur J Endocrinol 2013; 169: 127-32.
CR  - Colao A, Ferone D, Marzullo P, Lombardi G. Systemic complications of acromegaly: epidemiology, pathogenesis, and management. Endocr Rev 2004; 25: 102-52.
CR  - Chen YL, Wei CP, Lee CC, Chang TC. Diabetic ketoacidosis in a patient with acromegaly. J Formos Med Assoc 2007; 106: 788-91.
CR  - Dosi RV, Patell RD, Shah PJ, Joshi HK. Diabetic ketoacidosis: an unusual presentation of acromegaly. BMJ Case Rep 2013; doi:10.1136/bcr-2013-010198.
CR  - Jiang HJ, Hung WW, Hsiao PJ. A case of acromegaly complicated with diabetic ketoacidosis, pituitary apoplexy, and lymphoma. Kaohsiung J Med Sci 2013; 29: 687-90.
CR  - Vijayakumar A, Novosyadlyy R, Wu Y, Yakar S, LeRoith D. Biological effects of growth hormone on carbohydrate and lipid metabolism. Growth Horm IGF Res 2010; 20: 1-7.
CR  - Palakawong P, Arakaki R. Diabetic Ketoacidosis in Acromegaly: A Case Report. Endocr Pract 2012: 1-15.
CR  - Kinoshita Y, Fujii H, Takeshita A, et al. Impaired glucose metabolism in Japanese patients with acromegaly is restored after successful pituitary surgery if pancreatic {beta}-cell function is preserved. Eur J Endocrinol 2011; 164: 467-73.
UR  - https://dergipark.org.tr/tr/pub/aatd/issue//468398
L1  - https://dergipark.org.tr/tr/download/article-file/808190
ER  -