TY  - JOUR
T1  - The usefulness of monocyte to high density lipoprotein cholesterol ratio in prediction for coronary artery ectasia
TT  - Monosit/yüksek yoğunluklu lipoprotein oranının koroner arter ektaziyi öngörmedeki yararı
AU  - Çinar, Tufan
AU  - Tosu, Aydın Rodi
AU  - Güler, Arda
AU  - Kahraman, Serkan
AU  - Gürbak, İsmail
PY  - 2019
DA  - March
DO  - 10.18663/tjcl.478377
JF  - Turkish Journal of Clinics and Laboratory
JO  - TJCL
PB  - DNT Ortadoğu Yayıncılık A.Ş.
WT  - DergiPark
SN  - 2149-8296
SP  - 68
EP  - 73
VL  - 10
IS  - 1
LA  - en
AB  - Aim: Monocyte count to highdensity lipoprotein cholesterol ratio (MHR) has been shown to be a useful inflammatory markerin patients with coronary artery disease. Hence, theaim of the study was to evaluate whether there is an association betweencoronary artery ectasia (CAE) and MHR. Materialand methods: In this retrospective case-control study, a total of 5500patients who underwent an elective coronary angiography between July 2013 andJuly 2016 were retrospectively screened. Of thesepatients, 150 (2.7%) patients were found to have an isolated CAE. Thecontrol group was consisted of 150 normal coronary arterypatients who matched with this group in terms of age, gender, and body massindex. Results: The median value of MHR was found to be a statistically higher inpatients with CAE (p<0.05). Inmultivariable analyses, MHR (OR: 1.71, 95% CI: 1.219-2.484, p=0.002) was found to be an independentpredictor of CAE.Conclusion: We observed that MHR levels were higher in CAE patients when comparedto healthy subjects. Our findings may indicate a common pathophysiologicalmechanism between CAE and coronary artery disease.
KW  - MHR
KW  - inflammation
KW  - coronary artery ectasy
N2  - Amaç: Monosit sayısının yüksek yoğunluklu lipoprotein kolesteroleoranı (MYYLKO) koroner arter hastalığı olan hastalarda yararlı bir enflamasyonbelirteci olduğu gösterilmiştir. Bu nedenle, çalışmamızdaki amacımız MYYLKO’nınkoroner arter ektazi (KAE) arasında ilişki olup olmadığını araştırmaktı.Gereç ve yöntemler: Geriyedönük vaka-kontrol çalışmasında, Temmuz2013 ve Temmuz 2016 tarihleri arasında elektif koroner anjiyografi olan toplam5500 hasta tarandı. Bu hastalardan, 150 (2,7%) hastada KAE bulundu. Kontrolgrubu yaş, cinsiyet ve vücut kitle indeksi açısından eşleşen 150 normal koronerarter hastalarından oluştu. Bulgular:MYYLKO’nın ortanca değeri istatistiksel olarak KAEhastalarında daha yüksek bulundu (p<0.05).Çokludeğişken analizde, MYYLKO (Odds oranı:1.71, 95%Güven Aralığı:1.219-2.484, p=0.002) KAE’nin bağımsız öngörücüsüolarak saptandı. Sonuç:MYYLKO’nın KAE’li hastalarda sağlıklı kişilere göredaha yüksek olduğunu gözlemledik. Bu bulgularımız KAE ile koroner arterhastalığının ortak bir patofizyolojik mekanizmayı işaret edebilir.
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UR  - https://doi.org/10.18663/tjcl.478377
L1  - https://dergipark.org.tr/tr/download/article-file/676462
ER  -