@article{article_480073, title={PIPERIDINIUM 2-((5-(FURAN-2-YL)-4-PHENYL-4H-1,2,4-TRIAZOL)-3- YL) ACETATE FORCED DEGRADATION STUDY}, journal={Journal of Faculty of Pharmacy of Ankara University}, volume={43}, pages={117–134}, year={2019}, DOI={10.33483/jfpau.480073}, author={Varynskyi, Borys}, keywords={ESI kütle spektrometresi, triazoller, yüksek basınçlı sıvı kromatografisi, zorlanmış bozunma çalışması}, abstract={<div style="border:solid 1pt;padding:1pt 5pt 1pt 4pt;"> <p class="MsoNormal" style="margin-bottom:.0001pt;text-align:justify;text-indent:1cm;line-height:150%;border:none;padding:0cm;"> <b> <span lang="en-us" style="font-size:10pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us">O </span> </b> <b> <span lang="uk" style="font-size:10pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="uk">bjective </span> </b> <b> <span lang="en-us" style="font-size:10pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us">: </span> </b> <span lang="en-us" style="font-size:10pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us"> </span> <span lang="uk" style="font-size:10pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="uk">Aim of the research to make forced degradation study of piperidinium
2-((5- (furan-2-yl)-4-phenyl-4H-1,2,4-triazol-3-yl) acetate in active pharmaceutical
ingredient </span> <span lang="en-us" style="font-size:10pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us"> (API) </span> <span lang="uk" style="font-size:10pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="uk">, 0.1% solution and 1% solution for injection. </span> <span lang="uk" style="font-size:10pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="uk"> </span> <span lang="en-us" style="font-size:10pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us">I </span> <span lang="uk" style="font-size:10pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="uk">nfluence of
the sodium hydroxide, hydrochloride acid, 3% Н <sub>2 </sub>О <sub>2 </sub>,
temperature, UV radiation on piperidine 2-((5-(furan-2-yl)
-4-phenyl-4H-1,2,4-triazol-3-yl) acetate substance, 0.1% solution and 1%
solution for injections was studied. </span> <span lang="uk" style="font-size:10pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="uk"> </span> <b> <span lang="en-us" style="font-size:10pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us">Material and method: </span> </b> <span lang="en-us" style="font-size:10pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us">Agilent 1260 Infinity HPLC System. </span> <span lang="uk" style="font-size:10pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="uk"> Agilent single-quadrupole mass spectrometer 6120 </span> <span lang="en-us" style="font-size:10pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us">. <b>Result
and discussion: </b> </span> <span lang="uk" style="font-size:10pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="uk">Dependence of the quantitative content of the piperidinium
2-((5-(furan-2-yl)-4-phenyl-4H-1,2,4-triazol-3-yl) acetate from exposition time
was determined. </span> <span lang="uk" style="font-size:10pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="uk"> </span> <span lang="uk" style="font-size:10pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="uk">The composition of impurities formed under the action of an oxidizer was
established (3%Н <sub>2 </sub>О <sub>2 </sub>). This is sulfoxide and sulfone
corresponding to the API. </span> <span lang="uk" style="font-size:10pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="uk"> </span> <span lang="uk" style="font-size:10pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="uk">The composition of impurities which were formed under the influence of UV
radiation was proposed. </span> </p> <p> <i> </i> </p> <i> </i> </div>}, number={2}, publisher={Ankara Üniversitesi}