TY  - JOUR
T1  - PIPERIDINIUM 2-((5-(FURAN-2-YL)-4-PHENYL-4H-1,2,4-TRIAZOL)-3- YL) ACETATE FORCED DEGRADATION STUDY
TT  - PİPERİDİNYUM 2-((5-(FURAN-2-İL)-4-FENİL-4H-1,2,4-TRİAZOL)-3-İL) ASETATIN ZORLANMIŞ BOZUNMA ÇALIŞMASI
AU  - Varynskyi, Borys
PY  - 2019
DA  - June
Y2  - 2019
DO  - 10.33483/jfpau.480073
JF  - Journal of Faculty of Pharmacy of Ankara University
JO  - J. Fac. Pharm. Ankara
PB  - Ankara Üniversitesi
WT  - DergiPark
SN  - 1015-3918
SP  - 117
EP  - 134
VL  - 43
IS  - 2
LA  - en
AB  - Objective: Aim of the research to make forced degradation study of piperidinium2-((5- (furan-2-yl)-4-phenyl-4H-1,2,4-triazol-3-yl) acetate in active pharmaceuticalingredient (API), 0.1% solution and 1% solution for injection. Influence ofthe sodium hydroxide, hydrochloride acid, 3% Н2О2,temperature, UV radiation on piperidine 2-((5-(furan-2-yl)-4-phenyl-4H-1,2,4-triazol-3-yl) acetate substance, 0.1% solution and 1%solution for injections was studied. Material and method: Agilent 1260 Infinity HPLC System. Agilent single-quadrupole mass spectrometer 6120. Resultand discussion: Dependence of the quantitative content of the piperidinium2-((5-(furan-2-yl)-4-phenyl-4H-1,2,4-triazol-3-yl) acetate from exposition timewas determined. The composition of impurities formed under the action of an oxidizer wasestablished (3%Н2О2). This is sulfoxide and sulfonecorresponding to the API. The composition of impurities which were formed under the influence of UVradiation was proposed.
KW  - ESI mass spectrometry
KW  - forced degradation stuy
KW  - high pressure liquid chromatography
KW  - triazoles
N2  - Amaç: Bu araştırmanın amacı; aktif farmasötik içerikteki (API) 2-((5-(furan-2-İl)-4-fenİl-4H-1,2,4-trİazol)-3-İl)asetat maddesinin % 0.1 çözeltisinin ve enjeksiyonluk % 1 çözeltisininzorlanmış bozunmasının incelenmesidir. Çalışma, sodyum hidroksit, hidroklorikasit,% 3 H2O2, sıcaklık ve UV radyasyonunda bulunan piperidinyum2–((5-(furan-2-il)-4-fenil-4H-1,2,4-triazol)-3-il) asetatın % 0.1 çözelti veenjeksiyonluk % 1'lik çözeltisinde gerçekleştirilmiştir.Gereç ve Yöntem: Agilent 1260 Infinity HPLC Sistemi. Agilent dört kutuplu kütlespektrometresi 6120.   Sonuç ve Tartışma: Piperidinyum 2-((5-(furan-2-il)-4-fenil-4H-1,2,4-triazol)-3-il)asetatın kantitatif içeriğinin, maruz kalma süresine bağlı olduğubelirlenmiştir. Oksitleyicinin (% 3 Н2О2) etkisi altındaoluşan bozunma ürünlerinin bileşimi gösterilmiştir. UV radyasyonunun etkisi altında oluşan bozunmaürünlerinin bileşimi önerilmiştir.
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UR  - https://doi.org/10.33483/jfpau.480073
L1  - https://dergipark.org.tr/tr/download/article-file/729673
ER  -