@article{article_481237, title={Endothelin-1 levels in serum and cerebrospinal fluid after vasospasm following spontaneous subarachnoid haemorrhage}, journal={Cukurova Medical Journal}, volume={44}, pages={334–340}, year={2019}, DOI={10.17826/cumj.481237}, url={https://izlik.org/JA64UF23XH}, author={Bilgin, Emre and Oktay, Kadir and Olguner, Semih Kıvanç and Çavuş, Gökhan and Açık, Vedat and Arslan, Ali and Tuna, Metin}, keywords={Endotelin-1,subaraknoid kanama,vazospazm}, abstract={<p class="MsoNormal" style="margin:0cm 2.25pt .0001pt 0cm;line-height:200%;"> <span lang="en-gb" xml:lang="en-gb">Purpose: </span>The aim of the present study was to
analyse endothelin-1 levels in serum and cerebrospinal fluid samples in
patients with subarachnoid haemorrhage and evaluated the effects on vasospasm. <span lang="en-gb" xml:lang="en-gb"> </span> </p> <p> </p> <p class="MsoNormal" style="margin:0cm 2.15pt .0001pt 0cm;line-height:200%;"> <span lang="en-gb" xml:lang="en-gb">Material and
Methods: </span> <span lang="en-gb" xml:lang="en-gb">The patients were
selected among those who referred to intensive care unit of neurosurgery
department within several hours following subarachnoid
haemorrhage. Subarachnoid haemorrhage
was diagnosed through cerebral computed
tomography and lumbar punction. First neurological examinations of the
patients were evaluated according to Hunt-Hess classification and the blood
quantity was detected by cerebral computed
tomography according to Fisher classification. </span> <span lang="en-gb" xml:lang="en-gb"> </span> </p> <p> </p> <p class="MsoNormal" style="margin:0cm 2.15pt .0001pt 0cm;line-height:200%;"> <span lang="en-gb" xml:lang="en-gb">Results: </span> <span lang="en-gb" xml:lang="en-gb">Serum and cerebrospinal fluid samples of 20 patients enrolled into the
present study were collected at days 1, 3, 5, and 7 after subarachnoid haemorrhage. Ten individuals
without any vascular diseases, nervous system trauma or inflammatory disease
were enrolled into the study as the control group. Samples were analyzed
through micro-ELISA method and endothelin-1 levels in the serum and cerebrospinal fluid were detected. According
to Hunt-Hess classification, 6 patients were evaluated as Stage I, 10 patients
as Stage II, 2 patients as Stage III and 2 patients as Stage IV. Seventeen
patients were detected as Stage II whereas 3 patients were Stage IV according to
Fisher classification. Vasospasm was detected in cases 3, 6, 11 and 18 by
digital subtraction angiography. </span> <span lang="en-gb" xml:lang="en-gb"> </span> </p> <p> </p> <p class="MsoNormal" style="margin:.15pt 2.1pt .0001pt 0cm;line-height:200%;"> <span lang="en-gb" xml:lang="en-gb">Conclusion: </span> <span lang="en-gb" xml:lang="en-gb">It was determined
that as the Fisher and Hunt-Hess classifications increased, the risk of
cerebral vasospasm increased. The present study revealed that endothelin-1
levels increase after subarachnoid
haemorrhage and Endothelin-1 particularly may play an important role in
the vasospasm following spontaneous subarachnoid
haemorrhage. </span> <span lang="en-gb" xml:lang="en-gb"> </span> </p> <p> </p>}, number={2}