TY  - JOUR
T1  - TÜKÜRÜK BEZİNDE PLEOMORFİK ADENOMLARIN İNCELENMESİ, İNCE İĞNE ASPİRASYON SİTOLOJİSİNİN DOKU BİYOPSİSİ İLE KORELASYONU
TT  - INVESTIGATION OF PLEOMORPHIC ADENOMAS IN SALIVARY GLAND, CORRELATION BETWEEN TISSUE BIOPSY AND FINE NEEDLE ASPIRATION CYTOLOGY
AU  - Aslan, Figen
AU  - Küçük, Ülkü
PY  - 2020
DA  - January
Y2  - 2019
DO  - 10.18229/kocatepetip.482856
JF  - Kocatepe Tıp Dergisi
JO  - KTD
PB  - Afyonkarahisar Sağlık Bilimleri Üniversitesi
WT  - DergiPark
SN  - 3061-9904
SP  - 30
EP  - 34
VL  - 21
IS  - 1
LA  - tr
AB  - AMAÇ: Pleomorfik adenom, tükürükbezinin en sık görülen tümörüdür fakattümörün özelliklerini yansıtan çok az sayıda çalışma bulunmaktadır.Amacımız bu tümörün histopatolojik ve klinikopatolojik özelliklerini incelemekayrıca ince iğne aspirasyon sitolojisinin özelliklerini ve doku biopsisi ileuyumunu araştırmak.GEREÇ VEYÖNTEM:Pleomorfik adenom tanısı alan 85 olgu incelendi. Olguların demografiközellikleri, klinikopatolojik özellikleri ve operatif verileri retrospektifolarak kaydedildi. Operasyondan öncekiİİAB sonuçları dökümante edildi ve İİAB sonuçlarının doku biopsisi ileuyumu değerlendirildi.BULGULAR: Olgularımızda erkek-kadın oranı: 1/1.96 ve yaşortalaması 44.45 idi (11-87). Olgularımızın çoğu 40-59 yaş aralığındaydı(%41.57). Tümör en fazla (%59) parotis bezinde, 2. sıklıkta (%18) minör tükürükbezlerinde görüldü. Ortalama tümör çapı 3.23 cm idi (1-9 cm) ve tümör çapı ensık (%57.30) 2-4 cm aralığındaydı. Klasik tip en fazla görülen (%94.4) histolojiktipti. Rekürrens benign olguların sadece 1’inde (%1.40) görüldü. Tümördemalign transformasyon olgularımızın 5’inde (% 5.61) vardı. Operasyondan önceyapılan İİAB ile %80.32 gibi yüksek oranda PA tanısı verilmişti. SONUÇ: Pleomorfik adenom en fazlaparotis bezinde görülür ve burada da çoğunlukla yüzeyel lobda yerleşir. 4.-5. dekadlarda ve kadın cinsiyettedaha sıktır. Tümör çapı 2-4 cm aralığında daha fazla görülür. Tümörün düşükoranda nüks ve malign transformasyonolasılığı vardır. Preoperatif İİAB’nin tanısal doğruluğu oldukça yüksektir veİİAB yapılması doğru tedavi yaklaşımı açısından çok önemlidir.ANAHTARKELİMELER: pleomorfikadenom, tükürük bezi, tümör, İİABABSTRACTOBJECTIVE: Pleomorphic adenoma is the mostcommon tumor of the salivary gland but there are very few studies that reflectthe characteristics of the tumor. Our aim is to investigate the histopathologicaland clinicopathological features of this tumor and to investigate thecharacteristics of fine needle aspiration cytology and its compatibility withtissue biopsy.MATERIAL ANDMETHODS:85 cases with pleomorphic adenoma were evaluated. The demographiccharacteristics, clinicopathological features and operative data of thepatients were recorded retrospectively. The results of FNAB before theoperation were documented and the compliance of FNAB results with tissue biopsywas evaluated.RESULTS: The male to female ratio in our patients was 1/1.96 and the mean age was44.45 (11-87). Most of our cases were in the 40-59 age range (41.57%). The tumor was seen in the parotid gland in the majority (59%) and in theminor salivary glands in the 2nd order (18%). The mean tumor diameter was 3.23cm (1-9 cm) and the tumor diameter was most frequent (57.30%) in the range of2-4 cm.The classical type was the most common (94.4%) histological type.Recurrence was seen in only 1 (1.40%) of benign cases. Malignant transformationin the tumor was present in 5 (5.61%) cases. The diagnosis of PA was as high as 80.32%with preoperative FNAB. CONCLUSIONS: Pleomorphic adenoma is mostoften seen in the parotid gland and is usually located in the superficial lobe.It is more frequent in the 4th to 5th decade and in the female gender. Tumordiameter is more in the range of 2-4 cm. The tumor has a low rate of recurrenceand malignant transformation. Preoperative FNAB has a high diagnostic accuracyand FNAB is very important for the correct treatment approach.KEYWORDS: Pleomorphic adenoma, salivary gland, tumor, FNAB
KW  - pleomorfik adenom
KW  - tükürük bezi
KW  - tümör
N2  - OBJECTIVE: Pleomorphic adenoma is the most com-mon tumor of the salivary gland but there are very few studies that reflect the characteristics of the tumor. Our aim is to investigate the histopathological and clinico-pathological features of this tumor and to investigate the characteristics of fine needle aspiration cytology and its compatibility with tissue biopsy.MATERIAL AND METHODS: 85 cases with pleomorphic adenoma were evaluated. The demographic characteris-tics, clinicopathological features and operative data of the patients were recorded retrospectively. The results of fine needle aspiration biopsy (FNAB) before the ope-ration were documented and the compliance of FNAB results with tissue biopsy was evaluated.RESULTS: The male to female ratio in our patients was 1/1.96 and the mean age was 44.45 (11-87). Most of our cases were in the 40-59 age range (41.57%). The tumor was seen in the parotid gland in the majority (59%) and in the minor salivary glands in the 2nd order (18%). The mean tumor diameter was 3.23 cm (1-9 cm) and the tu-mor diameter was most frequent (57.30%) in the range of 2-4 cm. The classical type was the most common (94.4%) histological type. Recurrence was seen in only 1 (1.40%) of benign cases. Malignant transformation in the tumor was present in 5 (5.61%) cases. The diagnosis of pleo-morphic adenoma was as high as 80.32% with preope-rative FNAB.CONCLUSIONS: Pleomorphic adenoma is most often seen in the parotid gland and is usually located in the su-perficial lobe. It is more frequent in the 4th to 5th decade and in the female gender. Tumor diameter is more in the range of 2-4 cm. The tumor has a low rate of recurrence and malignant transformation. Preoperative FNAB has a high diagnostic accuracy and FNAB is very important for the correct treatment approach.
CR  - Gurung  U, Shrestha BL, Sinha BK, et al. Pleomorphic adenoma of salivary glands: An experience at TUTH. Nepalese Journal of ENT Head and Neck Surgery  2010; 1(1): 8-11.
CR  - Mendenhall WM, Mendenhall CM, Werning JW, et al. Salivary gland pleomorphic adenoma. American journal of clinical oncology 2008; 31(1): 95-9.
CR  - Al-Khtoum N, Qubilat AR, Al-Zaidaneen S, et al. Clinical characteristics of pleomorphic adenoma of salivary glands among Jordanian patients. J Pak Med Assoc 2013; 63(3): 358-60.
CR  - Gahine R, Sudarshan V, Hussain N, et al. Pleomorphic adenoma: A diagnostic pitfall in the diagnosis of salivary gland lesions on FNAC: Case reports with review of the literature. Cytojournal 2010; 7.
CR  - Sathyaki DC, Gayathri R, Roy MS, et al. Pleomorphic Adenoma: An Observational Study. International Journal of Scientific Study 2016; 4(9): 115-8.
CR  - Valstar M, de Ridder M, van den Broek EC, et al. Salivary gland pleomorphic adenoma in the Netherlands: A nationwide observational study of primary tumor incidence, malignant transformation, recurrence, and risk factors for recurrence. Oral Oncology 2017; 66 :93-9.
CR  - Ito FA, Jorge J, Vargas PA, Lopes, MA. Histopathological findings of pleomorphic adenomas of the salivary glands. Medicina Oral Patologia Oral Y Cirugia Bucal 2009;14(2): 57-61.
CR  - Fonseca FP, de Vasconcelos Carvalho M, de Almeida OP, et al. Clinicopathologic analysis of 493 cases of salivary gland tumors in a Southern Brazilian population. Oral surgery, oral medicine, oral pathology and oral radiology 2012; 114(2): 230-9.
CR  - Fu H, Wang J, Wang L, Zhang Z,  He Y. Pleomorphic adenoma of the salivary glands in children and adolescents. Journal of pediatric surgery 2012; 47(4): 715-9.
CR  - Nezhad MJ, Moghadam SA,  Mokhtari S, et al. Different Histolopathologic Features of Pleomorphic Adenoma in Salivary Glands. International Journal of Oral & Maxillofacial Pathology 2013; 4(2): 07-11.
CR  - Satpathy Y, Spadigam AE, Dhupar A, et al. Epithelial and stromal patterns of pleomorphic adenoma of minor salivary glands: A histopathological and histochemical study. Journal of oral and maxillofacial pathology: JOMFP 2014; 18(3): 379.
CR  - De Silva MN, Kosgoda KMS, Tilakaratne WM, et al. A case of giant pleomorphic adenoma of the parotid gland. Oral Oncology Extra 2004; 40(3): 43-5.
CR  - Abu‐Ghanem Y, Mizrachi A, Popovtzer A, et al. Recurrent pleomorphic adenoma of the parotid gland: institutional experience and review of the literature. Journal of surgical oncology 2016; 114(6): 714-8.
CR  - Bradley PJ. Recurrent salivary gland pleomorphic adenoma: etiology, management, and results. Current Opinion in Otolaryngology & Head and Neck Surgery 2001; 9(2): 100-8.
CR  - Heaton CM, Chazen JL, Van Zante A, et al. Pleomorphic adenoma of the major salivary glands: diagnostic utility of FNAB and MRI. The Laryngoscope 2013; 123(12): 3056-3060.
UR  - https://doi.org/10.18229/kocatepetip.482856
L1  - http://dergipark.org.tr/tr/download/article-file/926406
ER  -