@article{article_487173, title={THE RESEARCH OF 1,2,4-TRIAZOLE DERIVATIVES HEPATOPROTECTIVE ACTIVITY UNDER TETRACYCLINE AND INFECTIOUS HEPATITIS}, journal={Journal of Faculty of Pharmacy of Ankara University}, volume={43}, pages={135–146}, year={2019}, DOI={10.33483/jfpau.487173}, author={Shcherbyna, Roman and Vashchyk, Yevgenia}, keywords={biyokimyasal belirteçler, karaciğer koruyucu aktivite, 1.2.3-triazol}, abstract={<p class="MsoNormal" style="text-align:justify;text-indent:42.55pt;line-height:150%;"> <b> <span lang="en-us" style="font-size:10pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us">Objectives: </span> </b> <span lang="en-us" style="font-size:10pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us">The purpose of this work is to study
the hepatoprotective properties of potassium 2-((4-amino-5-
(morpholinomethyl)-4H-1,2,4-triazole-3-yl)thio)acetate on tetracycline and
infectious hepatitis models in chickens. </span> </p> <p> </p> <p class="MsoNormal" style="text-align:justify;text-indent:42.55pt;line-height:150%;"> <b> <span lang="en-us" style="font-size:10pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us">Materials
and Methods: </span> </b> <span lang="en-us" style="font-size:10pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us">Biochemical examination of blood and
liver serum was carried out on intact broiler chickens Cobb 500 cross. All
groups of chickens were kept separate in different cells in the same room for the
same microclimate parameters in accordance with the established requirements. </span> </p> <p> </p> <p class="MsoNormal" style="text-align:justify;text-indent:42.55pt;line-height:150%;"> <b> <span lang="en-us" style="font-size:10pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us">Result and Discussion </span> </b> <b> <span lang="en-us" style="font-size:10pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us">: </span> </b> <span lang="en-us" style="font-size:10pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us">As a result of research on the model
of hepatitis in chickens caused by tetracycline, established hepatoprotective
effect of potassium compound
2-((4-amino-5-(morpholinomethyl)-4H-1,2,4-triazole-3-yl)thio)acetate,  which is not inferior to the referent drug - <b>Thiotriazolin <sup>® </sup> </b>. Based on the
results of the biochemical study, hepatoprotective properties of the
combination of the above compound with the antibiotic <b>Saroflox <sup>® </sup> </b>, combination of potassium 2-((4-amino-5-
(morpholinomethyl)-4H-1,2,4-triazole-3-yl) thio) acetate with  classical antibiotic <b>Enrofloxacin <sup>® </sup> </b> on the model of infectious hepatitis. </span> </p> <p> <i> </i> </p> <i> </i>}, number={2}, publisher={Ankara Üniversitesi}