TY - JOUR T1 - Konjenital Kalp Hastalıklarında Respiratuar Sinsisyal Virus Proflaksisinde Uygulama Protokolünün Hasta Uyumu Üzerine Etkisi ve Klinik Sonuçları TT - The Effects of Respiratory syncytial virus prophylaxis Application Protocol on Patient Compliance and Clinical Outcomes in Congenital Heart Diseases AU - Tosun, Öykü PY - 2019 DA - December DO - 10.16948/zktipb.495665 JF - Zeynep Kamil Tıp Bülteni PB - Zeynep Kamil Kadın ve Çocuk Hastalıkları EAH WT - DergiPark SN - 1300-7971 SP - 201 EP - 204 VL - 50 IS - 4 LA - tr AB - Giriş: Palivizumab, yüksek riskli çocuklarda respiratuarsinsisyal virüs (RSV) önlenmesinde iyi tolere edilen, güvenli bir monoklonalantikordur. Hastaların zamanında ve tam doz proflaksialabilmeleri için anne ve babanın uyumu son derece önemlidir. RSV proflaksisinde hasta uyumunu ve klinik sonuçlarını değerlendirenmakaleler bulunmaktadır. Her kliniğin kendi takip ve uygulama protokolübulunmaktadır ancak kullanılan protokoller, hasta uyumu ve doz tamamlanması ileilgili bir çalışma bulunmamaktadır.Hastalar ve Yöntem: Ekim 2016-Mart 2018tarihleri arasında çocuk kardiyoloji polikliniğinde RSV proflaksisi endikasyonualmış hemodinamik olarak anlamlı KKH’na sahip 2 yaş altı toplam 60 hastaya aitveriler çocuk kardiyoloji poliklinik ve servis kayıtlarından retrospektifolarak incelendi. 2 farklı sezonda, proflaksi endikasyonu alanve 2 farklı protokol ile takip edilen hastalar uyum ve klinik sonuçlaraçısından birbiriyle karşılaştırıldı. Tam uyum, sezon boyunca 5 aylık dönemde,30 gün aralarla en az 4 doz palivizumab uygulaması yapılması olarak tanımlandı.Bulgular:Ekim 2016- Mart 2017 sezonunda, 5 aylıkdönemde uygulan ortalama doz 1 ± 0.2 doz idi ve tam hasta uyumu %10olarak bulundu. Doz aralıkları 37.2 ± 6.15 gün olarak bulundu. 10 hastada (%40) ASYE nedeniyle hastaneye yatış ve RSV izolasyonu mevcuttu. Ekim 2017-Mart2018 sezonunda yapılan protokol değişikliği sonrası, hasta uyumu %100 olarakdeğerlendirildi, ASYE nedeniyle acil servis başvurusu ve hastaneye yatışgereksinimi tespit edilmedi. Sonuç: Palivizumabproflaksisinde doz tamamlanması ve aralığı uyumunu arttırmak RSV’ye bağlıhastane yatışlarını önemli ölçülde azaltmaktadır. Detaylı ve iyi organizeedilmiş takip ve uygulama protokolleri hazırlanmak uyumu arttırmada son dereceönemlidir. KW - Respiratuar Sinsisyal Virus KW - Konjenital Kalp Hastalıkları KW - KW - Uyum N2 - Introduction: Palivizumabis a well tolerated, safe monoclonal antibody in the prevention of respiratuarsyncytial virus (RSV) in high-risk children. The adaptation of the parents isextremely important for patients to be able to receive timely and full doseprophylaxis. There are articles evaluating patient compliance and clinicaloutcomes in RSV prophylaxis. Each clinic has its own follow-up and administrationprotocol, but there are no studies on the protocols used, patient complianceand dose completion.Materialand Methods: A total of 60 patients with hemodynamically significant congenital heartdisease who had RSV prophylaxis in the pediatric cardiology outpatient clinicbetween October 2016 and March 2018 were retrospectively reviewed. The patientswho received prophylaxis in 2 different seasons and were followed up with 2different protocols were compared with each other in terms of compliance andclinical results Results: In the October 2016- March 2017 season, the mean dose was 1 ± 0.2 inthe 5-month period and full patient compliance was 10%. Dose intervals were37.2 ± 6.15 days. 10 patients (40%) were hospitalized. 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