TY - JOUR T1 - Relationship Between Monocyte/High-Density Lipoprotein Cholesterol Ratio and Angiographic Severity and Extent of Coronary Artery Disease TT - Monosit Sayısı/HDL Oranı ile Koroner Arter Hastalığının Ciddiyeti ve Yaygınlığı Arasındaki İlişki AU - Sivri, Serkan AU - Kızıltunç, Emrullah AU - Alsancak, Yakup AU - Sezenöz, Burak AU - Özkan, Selçuk AU - Demir Alsancak, Aybüke AU - Taçoy, Gülten PY - 2017 DA - April JF - Koşuyolu Heart Journal PB - Kartal Koşuyolu Yüksek İhtisas EAH WT - DergiPark SN - 2149-2972 SP - 30 EP - 35 VL - 20 IS - 1 LA - en AB - Introduction:Circulatingmonocyte count is predictive of new atherosclerotic plaque development. Inaddition, there is a strong inverse relationship between high-densitylipoprotein (HDL) cholesterol and atherosclerosis. We aimed to investigate therelationship between the monocyte/HDL cholesterol ratio and severity ofcoronary artery disease.Patientsand Methods: A total of 760 patients who underwent coronaryangiography were included in the study. The severity of coronaryatherosclerosis was calculated by the Gensini score, and the patients weregrouped as having low (< 20) and high (> 20) Gensini scores. Baselinecharacteristics and laboratory parameters were recorded and compared betweenpatients with low and high Gensini scores. Results: Hypertension,diabetes mellitus, hyperlipidaemia, advanced age and smoking were more commonin patients with a high Gensini score. Fasting blood glucose levels, creatininelevels and monocyte/HDL cholesterol ratio were significantly lower in patientswith a low Gensini score than in those with a high Gensini score. Logisticregression analysis revealed that older age, fasting blood glucose levels,hyperlipidaemia, family history of coronary artery disease and male gender wereindependent predictors of a high Gensini score. We observed a correlationbetween the monocyte/HDL cholesterol ratio and Gensini score (p< 0.001).However, this correlation was weak (Spearman’s rho = 0.159).Conclusion: We observed a positive but weak correlationbetween the monocyte/HDL cholesterol; ratio and increased coronaryatherosclerotic burden, as calculated by Gensini scoring. Further studies arerequired to demonstrate the relationship between the monocyte/HDL cholesterolratio and atherosclerotic cardiovascular disease. KW - Monocyte count KW - high-density lipoprotein cholesterol KW - atherosclerosis KW - coronary artery disease KW - Gensini score N2 - Giriş: Kan dolaşımında bulunan monosit sayısı yeni aterosklerotik plak oluşumundaöngörücüdür. Bununla birlikte yüksek dansiteli lipoprotein kolesterol (HDL)düzeyleri ile ateroskleroz arasında güçlü bir negatif ilişki vardır. Buçalışmada, monosit sayısı/HDL oranıyla koroner arter hastalığı ciddiyetiarasındaki ilişkiyi değerlendirmeyi amaçladık.Hastalar veYöntem: Koroner anjiyografi yapılan toplam 760 hasta çalışmayadahil edildi. Koroner ateroskleroz ciddiyeti Gensini skorlama sistemikullanılarak değerlendirildi ve hastalar Gensini skorlarına göre yüksek (>20) ve düşük (< 20) olarak iki gruba ayrıldı. Bazal karakteristik özelliklerve laboratuvar parametreleri kaydedilerek yüksek ve düşük Gensini skoru olanhastalar arasında karşılaştırıldı.Bulgular: Hipertansiyon, diabetes mellitus, hiperlipidemi, ileri yaş ve sigaraiçiciliği yüksek Gensini skoru olan hastalarda daha fazlaydı. Açlık kan şekeri,kreatinin düzeyleri ve monosit/HDL oranı düşük Gensini skoru olan hastalardayüksek Gensini skoru olanlara kıyasla daha düşüktü. Lojistik regresyonanalizinde ileri yaş, açlık kan şekeri, hiperlipidemi, aile öyküsü ve erkekcinsiyetin yüksek Gensini skoru için bağımsız parametreler olduğu gözlendi.Monosit/HDL oranının, Gensini skoruyla korele olduğu (p< 0.001) ancak bukorelasyonun çok zayıf olduğu tespit edildi (Spearman’s Rho: 0.159).Sonuç: Monosit/HDL oranı ile Gensini skoruyla eldeedilen ateroskleroz yaygınlığı arasında zayıf da olsa bir ilişki izlenmiştir.Ancak Monosit/HDL oranı ve aterosklerotik kalp hastalığı arasındaki ilişkiyibelirlemek için daha fazla klinik çalışmaya ihtiyaç vardır. CR - 1. Ross R. Atherosclerosis-an inflammatory disease. N Engl J Med 1999;340:115-26. CR - 2. Imhof BA, Aurrand-Lions M. Adhesion mechanisms regulating the migration of monocytes. Nat Rev Immunol 2004;4:432-44. CR - 3. Greaves DR, Gordon S. The macrophage scavenger receptor at 30 years of age: current knowledge and future challenges. J Lipid Res 2009;50(Suppl): 282-6. CR - 4. 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