TY - JOUR T1 - Relationship Between Severity of Obstructive Sleep Apnea and PR Interval TT - Obstrüktif Uyku Apnesi Şiddeti ve PR Süresi Arasındaki İlişki AU - Karamanlı, Harun AU - Aygün, Fatih AU - Akgedik, Recep PY - 2016 DA - April JF - Koşuyolu Heart Journal PB - Kartal Koşuyolu Yüksek İhtisas EAH WT - DergiPark SN - 2149-2972 SP - 27 EP - 31 VL - 19 IS - 1 LA - en AB - Introduction:Relationship between obstructive sleep apnea (OSA)and electrocardiogram and OSA severity index relationship that may affect thePR interval were studied.Patientsand Methods: This study included 85 people who had OSAdiagnosed at our clinic between January 2013 and August 2013. Theirpolysomnography (PSG) reports were evaluated by physicians who are expert intheir fields. Individuals with severe OSA diseases were categorized as group 1,and individuals with mild to moderate OSA were categorized as group 2.Results: Agedistribution of individuals who participated to the study ranged from 20 yearsto 85 years (mean ± standard deviation, 45.5 ± 13.2 years). Fifty-one (60%) ofthose individuals were men, and 34 (40%) of them were women. The PR intervalfor the group who had severe OSA on PSG (group 1) was 163.1 ± 35.2 ms, and it was147.8 ± 29.3 in group 2.Conclusion: It was observed thatindividuals having severe OSA had higher PR intervals than individuals who hadmild to moderate OSA. It was determined that results were statisticallysignificant (p< 0.05, p= 0.032). We believe that apnea-hypopnea index,oxygen desaturation index, and arousal values, which are indications of OSAseverity and parameters of hypoxia-reoxygenation, contribute to PRprolongation. KW - PR interval time KW - sleep apnea obstructive N2 - Giriş: Obstriktif uykuapnesi (OSA) şiddeti ile elektrokardiyogramdaki PR süresinin genişlemesiarasındaki ilişki ve PR süresini etkileyebilecek OSA şiddet indeksleri ileilişkisi araştırılmıştır.Hastalar ve Yöntem: Bu çalışma;kliniğimizde Ocak 2013 ve Ağustos 2014 tarihleri arasında, OSA tanısı almış 85kişiyi içermektedir. Polisomnografi (PSG) raporları alanında uzman hekimtarafından değerlendirildi. Şiddetli uyku apne hastalığı olan bireyler grup 1olarak adlandırılırken, orta, hafif uyku apne hastalığı olan bireyler grup 2olarak belirlendi.Bulgular: Çalışmayakatılan tüm bireylerin yaş dağılımı; minimum 20 yıl, maksimum 85 yıldır(ortalama ± standart sapma 45.5 ± 13.2 y). Bu kişilerin 51’i (%60) erkek, 34’ü(%40) kadındır. Polisomnografi şiddetli OSA tanısı alan bireyleri içeren grup1’de PR süresi 163.1 ± 35.2 milisaniye (ms) iken grup 2’de 147.8 ± 29.3milisaniye olduğu görüldü.Sonuç: Şiddetli OSA tanısı alanbireylerin, hafif ve orta şiddette OSA tanısı alan bireylere göre PRsürelerinin yüksek olduğu görüldü. Sonucun istatiksel olarak anlamlı olduğutespit edildi (p< 0.05, p= 0). OSA şiddeti göstergesi vehipoksi-reoksijenizasyon parametreleri olan AHI (apne-hipopne indeksi), ODI(oksijen desaturasyon indeksi); arousal değerleri PR uzamasında katkısağladığına inanmaktayız. CR - 1. Bonsignore MR, Marrone O, Insalaco G, Bonsignore G. The cardiovascular effects of obstructive sleep apnoeas: analysis of pathogenic mechanisms. Eur Respir J 1994;7:786-805. CR - 2. Fletcher EC, DeBehnke RD, Lovoi MS, Gorin AB. Undiagnosed sleep apnea in patients with essential hypertension. Ann Intern Med 1985;103:190-5. CR - 3. Peker Y, Hedner J, Norum J, Kraiczi H, Carlson J. Increased incidence of cardiovascular disease in middle-aged men with obstructive sleep apnea: a 7-year follow-up. Am J Respir Crit Care Med 2002;166:159-65. CR - 4. Gami AS, Howard DE, Olson EJ, Somers VK. Day-night pattern of sudden death in obstructive sleep apnea. N Engl J Med 2005;352:1206-14. CR - 5. Huikuri HV, Castellanos A, Myerburg RJ, Sudden death due to cardiac arrhythmias. N Engl J Med 2001;345:1473-82. CR - 6. O’Driscoll DM, Meadows GE, Corfield DR, Simonds AK, Morrell MJ. Cardiovascular response to arousal from sleep under controlled conditions of central and peripheral chemoreceptor stimulation in humans. J Appl Physiol (1985) 2004;96:865-70. CR - 7. Otto ME, Belohlavek M, Romero-Corral A, Gami AS, Gilman G, Svatikova A, et al. Comparison of cardiac structural and functional changes in obese otherwise healthy adults with versus without obstructive sleep apnea. Am J Cardiol 2007;99:1298-302. CR - 8. Chung M-H, Kuo TBJ, Hsu N, Chu H, Chou K-R, Yang CCH. Sleep and autonomic nervous system changes - enhanced cardiac sympathetic modulations during sleep in permanent night shift nurses. Scand J Work Environ Health 2009;35:180-7. CR - 9. Bitter T, Horstkotte D, Oldenburg O. [Sleep disordered breathing and cardiac arrhythmias: mechanisms, interactions, and clinical relevance]. Dtsch Med Wochenschr 2011;136:431-5. CR - 10. Maeno K, Kasagi S, Ueda A, Kawana F, Ishiwata S, Ohno M, et al. Effects of obstructive sleep apnea and its treatment on signal-averaged P-wave duration in men. Circ Arrhythm Electrophysiol 2013;6:287-93. CR - 11. Somers VK, Dyken ME, Mark AL, Abboud FM. Parasympathetic hyperresponsiveness and bradyarrhythmias during apnoea in hypertension. Clin Auton Res 1992;2:171-6. CR - 12. Armour JA, Richer LP, Pagé P, Vinet A, Kus T, Vermeulen M, et al. Origin and pharmacological response of atrial tachyarrhythmias induced by activation of mediastinal nerves in canines. Auton Neurosci 2005;118:68-78. CR - 13. Budeus M, Hennersdorf M, Felix O, Reimert K, Perings C, Wieneke H, et al. Prediction of atrial fibrillation in patients with cardiac dysfunctions: P wave signal-averaged ECG and chemoreflexsensitivity in atrial fibrillation. Europace 2007;9:601-7. CR - 14. Burstein B, Nattel S. Atrial fibrosis: mechanisms and clinical relevance in atrial fibrillation. J Am Coll Cardiol 2008;51:802-9. UR - https://dergipark.org.tr/tr/pub/khj/issue//499550 L1 - https://dergipark.org.tr/tr/download/article-file/601211 ER -