TY - JOUR T1 - Characteristics of non-hepatic cancers in cirrhotic patients TT - Sirozlu hastalarda gelişen karaciğer dışı kanserlerin özellikleri AU - Akbaş, Enver AU - Altun, Reskan AU - Korkmaz, Murat PY - 2018 DA - December DO - 10.17941/agd.501918 JF - Akademik Gastroenteroloji Dergisi PB - Türk Gastroenteroloji Vakfı WT - DergiPark SN - 1303-6629 SP - 131 EP - 136 VL - 17 IS - 3 LA - en AB - Backgroundand Aims: Besides the incidenceof hepatocellular carcinoma, the incidence of some non-hepatic cancers alsoincreases in patients with cirrhosis. We evaluated whether there was anincrease in the incidence of non-hepatic cancers in patients with cirrhosisdiagnosed before transplantation in our center. Materialsand Methods: In this retrospective study, a total sample of 1017 patients with cirrhosis who were followedup at our center was reviewed, of which the data of 37patients who did not develop non-hepatic cancer were evaluated, and the incidence of cancer wasdetermined. These data werecompared with the incidence rate of cancer at our hospital.Results: The incidence of non-hepatic cancers was foundto be increased by 4-fold in males and by 9-fold in females (overall 7.5-fold)among patients with cirrhosis compared with that in the control group (p < 0.05).Comparison based on the type of cancers in cirrhotic patients revealed anincrease by 93-fold for leukemia, 33-fold for lymphoma, 31-fold for gallbladdercancers, 15.5-fold for gastric cancers, 12-fold for renal cell cancers, 10-foldfor sarcomas, 9-fold for urinary bladder cancers, ~6-fold for pancreatic,laryngeal, endometrial, and lung cancers, 4-fold for prostate cancers (p < 0.05), 2.5-fold for colon cancers, and 1.2-fold forbreast cancers (p˃ 0.05). Conclusion: There was an increase in the incidence of allnon-hepatic cancers, primarily lymphoma and leukemia, in patients withcirrhosis. KW - Cirrhosis KW - non-hepatic cancers KW - hepatocellular carcinoma N2 - Girişve Amaç: Sirozlu hastalarda hepatosellüler karsinom görülme sıklığınınartmasının yanında bazı karaciğer dışı kanserlerin görülme sıklığı daartmaktadır. Bizim merkezimizde transplantasyon öncesi takip edilen karaciğersirozlu hastalarda karaciğer dışı kanserlerin artıp artmadığını değerlendirdik. Gereç ve Yöntem: Bu retrospektif çalışmadamerkezimizde takip edilen 1017 sirozlu hastadan karaciğer dışı kanser gelişen37 hastanın verileri değerlendirildi ve kanser insidans oranları belirlendi. Buveriler hastanemize ait kanser insidans oranları ile karşılaştırıldı. Bulgular: Karaciğer dışı kanserleringörülme sıklığı kontrol grubuna göre erkeklerde 4 kat, kadınlarda 9 kat,toplamda ise 7,5 kat artmış idi (p<0,05). Sirozlu hastalardakanser türlerine göre kıyaslandığında ise lösemilerde 93 kat, lenfomalarda 33kat, safra kesesi kanserlerinde 31 kat, mide kanserlerinde 15,5 kat, renalhücreli kanserlerde 12 kat, sarkomlarda 10 kat, mesane kanserlerinde 9 kat, pankreas,larinks, endometrium ve akciğer kanserlerinde yaklaşık 6 kat, prostatkanserlerinde 4 kat (p <0,05), kolon kanserlerinde 2,5 kat, memekanserlerinde ise 1,2 kat artış söz konusu idi (p˃0,05). Sonuç: Sonuçolarak sirozlu hastalarda başta lenfoma ve lösemi olmak üzere bütün karaciğerdışı kanserlerin görülme sıklığı önemli oranda artmış olarak bulundu.  CR - 1. Goldberg E, Chopra S, Runyon BA. Overview of the complications, prognosis, and management of cirrhosis. UpToDate 2012. CR - 2. Conn H, Atterbury C. Cirrhosis. In: Schiff L, Schiff E (Eds), Diseases of the Liver, 7th edition, Lippincott Company, Philadelphia 1993;875. CR - 3. Berman K, Tandra S, Vuppalanchi R, et al. 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