TY  - JOUR
TT  - Regional Clinical and Biochemical Differences among Patients with Primary Hyperparathyroidism
AU  - Stamatin, Maria
AU  - Makay, Özer
AU  - Özçınar, Beyza
AU  - Şimşek, Turgay
AU  - Arıcı, Cumhur
AU  - Güngör, Bülent
AU  - Özbaş, Serdar
AU  - Akça, Tamer
AU  - Emre, Ali Uğur
AU  - Çakmak, Güldeniz Karadeniz
AU  - Akçay, Müfide
AU  - Ünal, Bülent
AU  - Girgin, Mustafa
AU  - Girgin, Sadullah
AU  - Görgülü, Semih
PY  - 2017
DA  - January
JF  - Balkan Medical Journal
PB  - Trakya Üniversitesi
WT  - DergiPark
SN  - 2146-3123
SP  - 28
EP  - 34
VL  - 34
IS  - 1
KW  - Hyperparathyroidism
KW  - clinocopathological features
KW  - regional differences
KW  - Turkey
KW  - Bulgaria
N2  - Background: Environmental habitat may play a role in clinical disparities of primary hyperparathyroidism (pHPT) patients. Aims: To compare preoperative clinical symptoms and associated conditions and surgical findings in patients with pHPT, living in different geographical regions from the Black Sea, Mediterranean and Anatolia regions. Study Design: Retrospective, clinical-based multicentric study of 694 patients with pHPT. Methods: Patients from 23 centers and 8 different geographical regions were included. Data related to baseline demographics, clinical, pathologic and treatment characteristics of 8 regions were collected and included age, gender, residential data, symptoms, history of fracture, existence of brown tumor, serum total Ca and p levels, serum parathormone (PTH) levels, serum 25-OH vitamin D levels, bone mineral density, size of the resected abnormal parathyroid gland(s), histology, as well as the presence of ectopia, presence of dual adenoma, and multiple endocrine neoplasia (MEN)- or familial-related disease. Results: The median age was 54. Asymptomatic patient rate was 25%. The median PTH level was 232 pg/mL and serum total Ca was 11.4 mg/dL. Eighty-seven percent of patients had an adenoma and 90% of these had a single adenoma. Hyperplasia was detected in 79 patients and cancer in 9 patients. The median adenoma size was 16 mm. Significant parameters differing between regions were preoperative symptoms, serum Ca and p levels, and adenoma size. All patients from South-East Anatolia were symptomatic, while the lowest p values were reported from East Anatolia and the largest adenoma size, as well as highest Ca levels, were from Bulgaria. Conclusion: Habitat conditions vary between geographical regions. This affects
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UR  - https://dergipark.org.tr/tr/pub/bmj/issue//502227
L1  - https://dergipark.org.tr/tr/download/article-file/606192
ER  -