TY  - JOUR
T1  - Development of an ultra-sensitive method using nafion and multi-walled carbon nanotube coated glassy carbon electrode for atenolol determination
TT  - Atenolol tayini için nafion ve çok duvarlı karbon nanotüp kaplı camsı karbon elektrot kullanılarak ultra hassas yöntem geliştirilmesi
AU  - Çelik Kazıcı, Hilal
PY  - 2018
DA  - December
JF  - Pamukkale Üniversitesi Mühendislik Bilimleri Dergisi
PB  - Pamukkale Üniversitesi
WT  - DergiPark
SN  - 2147-5881
SP  - 1287
EP  - 1292
VL  - 24
IS  - 7
LA  - en
AB  - Atenolol(Scheme 1) is antihypertensive drug that form β-blocker group, which widelyused in the treatment of hypertension In this study, the redox properties ofthe Tensinor drug used in blood pressure treatment were examined on modifiedglassy carbon electrode and the electrodes prepared by coating carbon nanotubeson this modified electrode. In order to investigate the effects of nafioncoated multi-walled glass nanotube (MWCNT / NGCE) electrode response and nafioncoated glassy carbon electrode (NGCE) and electrode responses of only glassycarbon electrode (GCE) surfaces on the support electrolyte, pH and scan rate,the cyclic voltammetry (CV) and differential pulse voltammetry (DPV) methodswere used. Atenolol (ATN) was observed in the Britton-Robinson (BR) buffersolution (pH 7.0) thereabouts 1.11 V (vsAg / AgCl (3.0 mol L-1 KCl). Voltammetricmethod reacted linear at a concentration range between 3x10-5 μM and 9x10-2 μMunder optimum analytical experimental conditions. The results of Tensinor'slimit of detection on the Britton-Robinson (BR) (pH=7) buffer were found to be7.67 x 10-5 mM and 2.5 x 10-4 mM, respectively. Additionally, in the study,interference effects experiments were performed with auxiliary substances usedin the preparation of medicines and no negative effect was observed.
KW  - Cyclic voltammetry
KW  - Atenolol
KW  - Carbon nano tube
N2  - Atenolol(Şekil 1), hipertansiyon tedavisinde yaygın olarak kullanılan β-bloker grubunuoluşturan antihipertansif ilaçtır. Bu çalışmada; Tansiyon tedavisindekullanılan Tensinör ilacının redoks özellikleri, modifiye camsı karbon elektrotve bu modifiye elektrot üzerine karbon nano tüp kaplanarak hazırlanmışelektrotlarda incelenmiştir. Nafion kaplı çok duvarlı karbon nanotüp (MWCNT/NGCE)elektrot yanıtı ile Nafion kaplı camsı karbon elektrot (NGCE) ve sadece camsıkarbon elektrot (GCE) yüzeylerinin elektrot yanıtlarının destek elektroliti,pH, ve tarama hızı üzerine etkilerini araştırmak için Çevrimsel voltametri (CV)ve Diferansiyel puls voltametri (DPV) yöntemleri kullanılmıştır. Atenolol (ATN)Britton-Robinson (BR) tampon çözeltisinde (pH 7.0) 1.11 V (vsAg/AgCl (3.0 molL-1 KC1) civarında gözlenmiştir. Voltametrik yöntem, optimum analitik deneykoşulları altında, 3x10-5 µM -9x10-2 mM konsantrasyon aralığında lineer tepkigöstermiştir. Britton-Robinson (BR) (pH=7) tamponundaki Tensinör belirme sınırısonuçları, sırasıyla 7.67 x 10-5 mM ve 2.5x10-4 mM olarak bulunmuştur. Ayrıcaçalışmada ilaçların hazırlanmasında kullanılan yardımcı maddeler ile girişimetkisi deneyleri gerçekleştirilmiş ve olumsuz bir etkiye rastlanmamıştır.
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UR  - https://dergipark.org.tr/tr/pub/pajes/issue//504303
L1  - https://dergipark.org.tr/tr/download/article-file/610218
ER  -