TY - JOUR T1 - Nötrofil / lenfosit oranı kronik hepatit B hastalarında karaciğer fibrozisini saptamada kullanılabilir mi? TT - Can neutrophil / lymphocyte ratio be used as a predictor of the hepatic fibrosis in chronic hepatitis B patients AU - Özer Sarı, Sevil AU - Köseoğlu, Hüseyin AU - Akar, Mustafa AU - Solakoğlu, Tevfik AU - Ersoy, Osman PY - 2019 DA - June DO - 10.19161/etd.504466 JF - Ege Tıp Dergisi JO - EJM PB - Ege Üniversitesi WT - DergiPark SN - 1016-9113 SP - 136 EP - 139 VL - 58 IS - 2 LA - tr AB - Amaç: Kronik hepatit B (KHB) hastalarında fibrozis değerlendirmesi siroz ve hepatosellüler kanser gelişiminiönlemek açısından önemlidir. Karaciğer biyopsisi fibrozisi değerlendirmek için altın standarttır. Karaciğer biyopsisinininvaziv olması ve komplikasyonlarının olması nedeniyle karaciğer histopatolojisini gösterecek noninvaziv testler önemkazanmıştır. Nötrofil/lenfosit oranının (NLO) nonalkolik steatohepatitli ve KHB'li hastalarda fibrozis ile ilişkisinigösteren bazı çalışmalar bulunmaktadır. Bu çalışmanın amacı KHB’li hastalarda NLO ile karaciğer fibrozisi arasındakiilişkiyi değerlendirmektir.Gereç ve Yöntem: Hepatoloji polikliniğimizce takip edilen ve karaciğer biyopsisi olan 67 KHB’li hasta retrospektifolarak değerlendirildi. Tüm hastaların demografik verileri, laboratuvar parametreleri ve karaciğer biyopsisindesaptanan değerler kaydedildi.Bulgular: Çalışmaya dahil edilen hastaların yaş ortalaması 48,6±11,7 yıl idi. 17 hasta kadın (%25,4), 50 hasta erkekti(%69,6). Fibrozis dereceleri 8 hastada 0, 15 hastada 1, 8 hastada 2, 18 hastada 3, 7 hastada 4, 9 hastada 5, 2hastada 6 olarak değerlendirildi. KHB hastalarında karaciğer biyopsisinde saptanan fibrozis ile NLO arasındakiilişkiye bakıldığında iki parametre arasında anlamlı bir ilişki saptanmadı (p=0,54).Sonuç: NLO oranı KHB'li hastalarda fibrozisi göstermede etkin bir parametre olarak görülmemiştir. KW - Kronik hepatit B KW - nötrofil/lenfosit oranı KW - fibrozis. N2 - Aim: Assessing fibrosis in chronic hepatitis B (CHB) patients is important in preventing cirrhosis and hepatocellularcancer development. Liver biopsy is the golden standard in evaluating fibrosis. Because liver biopsy is invasive andhas complications, non-invasive tests to demonstrate liver histopathology have become more important. There aresome studies that demonstrate the relationship between neutrophil/lymphocyte ratio (NLR) and fibrosis in nonalcoholic steatohepatitis and CHB patients. 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